DegronMD

Uniprot ID: P82094

Source protein: TATA element modulatory factor

Source gene: TMF1

Class: DEG_COP1_1

Location: 184:192

E3 ligase: COP1

DEGRON score: 0.7073

ASA_SCORE: 105.7778

COIL: 0.7992

CONS_SCORE: 0.3186

DSS_SCORE: 0.5058

HELIX: 0.134

FCONS_SCORE: 0.9839

RIG_SCORE: 0.7467

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T191A	TCGA-17-Z044	LUAD	TCGA	ESDMKVPTV	DEG_COP1_1	0.7139
p.I201T	TCGA-AJ-A3BG	UCEC	TCGA	ESDMKVPTV	DEG_COP1_1	0.0833
p.I201T	DO42633	UCEC	ICGC	ESDMKVPTV	DEG_COP1_1	0.0833
p.E178K	TCGA-AP-A056	UCEC	TCGA	ESDMKVPTV	DEG_COP1_1	0.1667
p.E178K	DO43971	UCEC	ICGC	ESDMKVPTV	DEG_COP1_1	0.1667
p.E179D	TCGA-B5-A3FC	UCEC	TCGA	ESDMKVPTV	DEG_COP1_1	0.1944
p.E179D	DO41871	UCEC	ICGC	ESDMKVPTV	DEG_COP1_1	0.1944
p.M187V	TCGA-GV-A3QH	BLCA	TCGA	ESDMKVPTV	DEG_COP1_1	0.6097
p.M187V	DO464	BLCA	ICGC	ESDMKVPTV	DEG_COP1_1	0.6097
p.M187V	SIDM00591	Oral Cavity Carcinoma	GDSC	ESDMKVPTV	DEG_COP1_1	0.6097
p.S185L	TCGA-VQ-A8PE	STAD	TCGA	ESDMKVPTV	DEG_COP1_1	0.6556
p.S185L	DO222572	MELA	ICGC	ESDMKVPTV	DEG_COP1_1	0.6556
p.S185L	DO51769	STAD	ICGC	ESDMKVPTV	DEG_COP1_1	0.6556
p.E198K	DO225117	BRCA	ICGC	ESDMKVPTV	DEG_COP1_1	0.1667
p.E198K	DO227878	BRCA	ICGC	ESDMKVPTV	DEG_COP1_1	0.1667
p.V192L	DO228349	MALY	ICGC	ESDMKVPTV	DEG_COP1_1	0.5654
p.V192L	SIDM00656	Burkitt's Lymphoma	GDSC	ESDMKVPTV	DEG_COP1_1	0.5654
p.V192L	SIDM00641	Burkitt's Lymphoma	GDSC	ESDMKVPTV	DEG_COP1_1	0.5654
p.V192L	ACH-000944	Lymphoma	CCLE	ESDMKVPTV	DEG_COP1_1	0.5654
p.V192L	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	ESDMKVPTV	DEG_COP1_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P82094	TATA element modulatory factor	DEG_COP1_1	184:192	ESDMKVPTV	COP1	0.7073	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons