DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
AGTSS
Uniprot ID:
P82094
Source protein:
TATA element modulatory factor
Source gene:
TMF1
Class:
DEG_SPOP_SBC_1
Location:
166:170
E3 ligase:
SPOP
DEGRON score:
0.9993
ASA_SCORE:
75.5
COIL:
0.9188
CONS_SCORE:
0.3067
DSS_SCORE:
0.6215
HELIX:
0.0296
FCONS_SCORE:
0.9853
RIG_SCORE:
0.5987
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S160L
TCGA-FW-A5DY
SKCM
TCGA
AGTSS
DEG_SPOP_SBC_1
0.6111
p.S160L
DO47257
SKCM
ICGC
AGTSS
DEG_SPOP_SBC_1
0.6111
p.G167S
TCGA-D7-A748
STAD
TCGA
AGTSS
DEG_SPOP_SBC_1
0.5882
p.G167S
DO50122
STAD
ICGC
AGTSS
DEG_SPOP_SBC_1
0.5882
p.E178K
TCGA-AP-A056
UCEC
TCGA
AGTSS
DEG_SPOP_SBC_1
0.1111
p.E178K
DO43971
UCEC
ICGC
AGTSS
DEG_SPOP_SBC_1
0.1111
p.E179D
TCGA-B5-A3FC
UCEC
TCGA
AGTSS
DEG_SPOP_SBC_1
0.0833
p.E179D
DO41871
UCEC
ICGC
AGTSS
DEG_SPOP_SBC_1
0.0833
Showing 1 to 8 of 8 entries
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Drug responses associated with TMF1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of AGTSS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P212
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
DEG_SPOP_SBC_1
1162:1166
AGTSS
SPOP
0.9841
More...
P16070
CD44 antigen
DEG_SPOP_SBC_1
265:269
AGTSS
SPOP
0.9527
More...
Q5VT06
Centrosome-associated protein 350
DEG_SPOP_SBC_1
1271:1275
AGTSS
SPOP
0.9877
More...
Q6ZP82
Coiled-coil domain-containing protein 141
DEG_SPOP_SBC_1
1253:1257
AGTSS
SPOP
0.9861
More...
Q8WV16
DDB1- and CUL4-associated factor 4
DEG_SPOP_SBC_1
58:62
AGTSS
SPOP
0.9954
More...
Q8TEH3
DENN domain-containing protein 1A
DEG_SPOP_SBC_1
775:779
AGTSS
SPOP
0.8732
More...
Q9HCR9
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
DEG_SPOP_SBC_1
56:60
AGTSS
SPOP
0.8678
More...
O95073
Fibrinogen silencer-binding protein
DEG_SPOP_SBC_1
134:138
AGTSS
SPOP
0.9917
More...
O95249
Golgi SNAP receptor complex member 1
DEG_SPOP_SBC_1
3:7
AGTSS
SPOP
0.9984
More...
Q03164
Histone-lysine N-methyltransferase 2A
DEG_SPOP_SBC_1
724:728
AGTSS
SPOP
0.999
More...
Q9HCC9
Lateral signaling target protein 2 homolog
DEG_SPOP_SBC_1
474:478
AGTSS
SPOP
0.7998
More...
O60244
Mediator of RNA polymerase II transcription subunit 14
DEG_SPOP_SBC_1
1147:1151
AGTSS
SPOP
0.9972
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
3117:3121
AGTSS
SPOP
0.9982
More...
Q9Y5A7
NEDD8 ultimate buster 1
DEG_SPOP_SBC_1
556:560
AGTSS
SPOP
0.9912
More...
Q8N4B5
Proline-rich protein 18
DEG_SPOP_SBC_1
119:123
AGTSS
SPOP
0.9888
More...
Q9H6K5
Proline-rich protein 36
DEG_SPOP_SBC_1
83:87
AGTSS
SPOP
0.9884
More...
Q9Y572
Receptor-interacting serine/threonine-protein kinase 3
DEG_SPOP_SBC_1
385:389
AGTSS
SPOP
0.9713
More...
Q9P0V3
SH3 domain-binding protein 4
DEG_SPOP_SBC_1
197:201
AGTSS
SPOP
0.9517
More...
Q5VWJ9
Sorting nexin-30
DEG_SPOP_SBC_1
63:67
AGTSS
SPOP
0.9979
More...
P82094
TATA element modulatory factor
DEG_SPOP_SBC_1
166:170
AGTSS
SPOP
0.9993
More...
Q99990
Transcription cofactor vestigial-like protein 1
DEG_SPOP_SBC_1
137:141
AGTSS
SPOP
0.8905
More...
Q5JYT7
Uncharacterized protein KIAA1755
DEG_SPOP_SBC_1
294:298
AGTSS
SPOP
0.9974
More...
Showing 1 to 22 of 22 entries
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