DegronMD

Uniprot ID: Q8TEH3

Source protein: DENN domain-containing protein 1A

Source gene: DENND1A

Class: DEG_SPOP_SBC_1

Location: 775:779

E3 ligase: SPOP

DEGRON score: 0.8732

ASA_SCORE: 64.2

COIL: 0.8328

CONS_SCORE: 0.282

DSS_SCORE: 0.4938

HELIX: 0.1398

FCONS_SCORE: 1.0068

RIG_SCORE: 0.6631

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T777M	TCGA-DF-A2KU	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	0.7423
p.T777M	DO228338	MALY	ICGC	AGTSS	DEG_SPOP_SBC_1	0.7423
p.T777M	DO223286	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.7423
p.D780N	TCGA-44-2665	LUAD	TCGA	AGTSS	DEG_SPOP_SBC_1	0.3056
p.D780N	DO23582	LUAD	ICGC	AGTSS	DEG_SPOP_SBC_1	0.3056
p.D780N	ACH-001802	Liposarcoma	CCLE	AGTSS	DEG_SPOP_SBC_1	0.3056
p.P772L	DO220886	MELA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.25
p.A784T	DO233889	GACA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784D	SIDM01096	Colorectal Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784D	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784D	SIDM00627	Cervical Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784D	SIDM01168	Colorectal Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784D	SIDM00265	Ewing's Sarcoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784D	SIDM00900	Non-Cancerous	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784D	SIDM00864	Cervical Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784D	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784D	SIDM00701	Non-Cancerous	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784D	SIDM01502	Endometrial Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784D	SIDM01323	Oral Cavity Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784S	SIDM01156	Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784S	ACH-000890	Lung Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A784S	SW1271	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.L785F	TCGA-CW-6093	KIRC	TCGA	AGTSS	DEG_SPOP_SBC_1	0.1667
p.L785F	DO16248	KIRC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1667

Showing 1 to 24 of 24 entries

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Drug responses associated with DENND1A mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AGTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1162:1166	AGTSS	SPOP	0.9841	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	265:269	AGTSS	SPOP	0.9527	More...
Q5VT06	Centrosome-associated protein 350	DEG_SPOP_SBC_1	1271:1275	AGTSS	SPOP	0.9877	More...
Q6ZP82	Coiled-coil domain-containing protein 141	DEG_SPOP_SBC_1	1253:1257	AGTSS	SPOP	0.9861	More...
Q8WV16	DDB1- and CUL4-associated factor 4	DEG_SPOP_SBC_1	58:62	AGTSS	SPOP	0.9954	More...
Q8TEH3	DENN domain-containing protein 1A	DEG_SPOP_SBC_1	775:779	AGTSS	SPOP	0.8732	More...
Q9HCR9	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	DEG_SPOP_SBC_1	56:60	AGTSS	SPOP	0.8678	More...
O95073	Fibrinogen silencer-binding protein	DEG_SPOP_SBC_1	134:138	AGTSS	SPOP	0.9917	More...
O95249	Golgi SNAP receptor complex member 1	DEG_SPOP_SBC_1	3:7	AGTSS	SPOP	0.9984	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	724:728	AGTSS	SPOP	0.999	More...
Q9HCC9	Lateral signaling target protein 2 homolog	DEG_SPOP_SBC_1	474:478	AGTSS	SPOP	0.7998	More...
O60244	Mediator of RNA polymerase II transcription subunit 14	DEG_SPOP_SBC_1	1147:1151	AGTSS	SPOP	0.9972	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3117:3121	AGTSS	SPOP	0.9982	More...
Q9Y5A7	NEDD8 ultimate buster 1	DEG_SPOP_SBC_1	556:560	AGTSS	SPOP	0.9912	More...
Q8N4B5	Proline-rich protein 18	DEG_SPOP_SBC_1	119:123	AGTSS	SPOP	0.9888	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	83:87	AGTSS	SPOP	0.9884	More...
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	385:389	AGTSS	SPOP	0.9713	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	197:201	AGTSS	SPOP	0.9517	More...
Q5VWJ9	Sorting nexin-30	DEG_SPOP_SBC_1	63:67	AGTSS	SPOP	0.9979	More...
P82094	TATA element modulatory factor	DEG_SPOP_SBC_1	166:170	AGTSS	SPOP	0.9993	More...
Q99990	Transcription cofactor vestigial-like protein 1	DEG_SPOP_SBC_1	137:141	AGTSS	SPOP	0.8905	More...
Q5JYT7	Uncharacterized protein KIAA1755	DEG_SPOP_SBC_1	294:298	AGTSS	SPOP	0.9974	More...

Showing 1 to 22 of 22 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGTSS

Degron related mutations and impact score

Drug responses associated with DENND1A mutations

All proteins holding degron of AGTSS