DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
PRR36
UniProt ID:
Q9H6K5
Entrez ID:
80164
Protein name:
Proline-rich protein 36
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
PRR36
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.P774S
SIDM01175
Other Sarcomas
GDSC
PLTTPHLE
DEG_SCF_FBW7_2
774:781
Mutation altering degron motif
0.6752
p.P774S
SW684
soft tissue
COSMIC
PLTTPHLE
DEG_SCF_FBW7_2
774:781
Mutation altering degron motif
0.6752
p.P812L
SIDM00710
Small Cell Lung Carcinoma
GDSC
PLTTPPPE
DEG_SCF_FBW7_2
797:804
Mutation rewiring degron network
0.1111
p.P756S
SIDM00254
Neuroblastoma
GDSC
PLTTPPLE
DEG_SCF_FBW7_2
751:758
Mutation altering degron motif
0.5641
p.L798F
ES4
bone
COSMIC
PLTTPPPE
DEG_SCF_FBW7_2
797:804
Mutation altering degron motif
0.587
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for PRR36 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc