DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PLTTPPPE
Uniprot ID:
Q9H6K5
Source protein:
Proline-rich protein 36
Source gene:
PRR36
Class:
DEG_SCF_FBW7_2
Location:
797:804
E3 ligase:
FBXW7
DEGRON score:
0.939
ASA_SCORE:
100.4
COIL:
0.9816
CONS_SCORE:
0
DSS_SCORE:
0.7807
HELIX:
0.0074
FCONS_SCORE:
0
RIG_SCORE:
0.5122
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P812L
SIDM00710
Small Cell Lung Carcinoma
GDSC
PLTTPPPE
DEG_SCF_FBW7_2
0.1111
p.L798F
ES4
bone
COSMIC
PLTTPPPE
DEG_SCF_FBW7_2
0.587
Drug responses associated with PRR36 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PLTTPPPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H6K5
Proline-rich protein 36
DEG_SCF_FBW7_2
797:804
PLTTPPPE
FBXW7
0.939
More...