DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PLTTPPLE
Uniprot ID:
Q9H6K5
Source protein:
Proline-rich protein 36
Source gene:
PRR36
Class:
DEG_SCF_FBW7_2
Location:
751:758
E3 ligase:
FBXW7
DEGRON score:
0.9265
ASA_SCORE:
96.9125
COIL:
0.9686
CONS_SCORE:
0
DSS_SCORE:
0.6578
HELIX:
0.0154
FCONS_SCORE:
0
RIG_SCORE:
0.6393
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P756S
SIDM00254
Neuroblastoma
GDSC
PLTTPPLE
DEG_SCF_FBW7_2
0.5641
Drug responses associated with PRR36 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PLTTPPLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H6K5
Proline-rich protein 36
DEG_SCF_FBW7_2
751:758
PLTTPPLE
FBXW7
0.9265
More...