DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PLTTPHLE
Uniprot ID:
Q9H6K5
Source protein:
Proline-rich protein 36
Source gene:
PRR36
Class:
DEG_SCF_FBW7_2
Location:
774:781
E3 ligase:
FBXW7
DEGRON score:
0.9762
ASA_SCORE:
105.275
COIL:
0.9694
CONS_SCORE:
0
DSS_SCORE:
0.6317
HELIX:
0.0125
FCONS_SCORE:
0
RIG_SCORE:
0.6001
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P774S
SIDM01175
Other Sarcomas
GDSC
PLTTPHLE
DEG_SCF_FBW7_2
0.6752
p.P774S
SW684
soft_tissue
COSMIC
PLTTPHLE
DEG_SCF_FBW7_2
0.6752
Drug responses associated with PRR36 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PLTTPHLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H6K5
Proline-rich protein 36
DEG_SCF_FBW7_2
774:781
PLTTPHLE
FBXW7
0.9762
More...