DegronMD - O60244(MED14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1057W	TCGA-2L-AAQJ	PAAD	TCGA	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.0833
p.L1057W	DO218949	PAAD	ICGC	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.0833
p.I1078V	TCGA-5P-A9JY	KIRP	TCGA	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.1667
p.I1078V	DO223944	KIRP	ICGC	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.1667
p.V1138A	TCGA-AJ-A3EL	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.0833
p.V1138A	DO41542	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.0833
p.G1148E	TCGA-AX-A0J0	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation altering degron motif	0.6087
p.G1148E	DO41133	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation altering degron motif	0.6087
p.A1063V	TCGA-BS-A0TJ	UCEC	TCGA	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.25
p.A1063V	DO42953	UCEC	ICGC	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.25
p.H1074R	TCGA-DD-AAVR	LIHC	TCGA	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.2778
p.H1074R	DO52278	LIHC	ICGC	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.2778
p.T1153I	TCGA-DF-A2KU	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.2778
p.T1153I	DO223286	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.2778
p.G1081W	TCGA-EE-A29G	SKCM	TCGA	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.0833
p.G1081W	DO47303	SKCM	ICGC	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.0833
p.P1145H	TCGA-EE-A2MD	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.2778
p.P1145H	DO37851	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.2778
p.P1137S	TCGA-EO-A22R	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.0556
p.P1137S	DO42713	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.0556
p.A1082T	TCGA-EO-A22R	UCEC	TCGA	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.0556
p.A1082T	DO42713	UCEC	ICGC	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.0556
p.S1064L	DO52434	COCA	ICGC	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.2778
p.P1159T	DO229036	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.1111
p.N1157K	DO229036	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.1667
p.T1068A	DO33091	PACA	ICGC	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation altering degron motif	0.7139
p.G1079V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.1389
p.G1079V	RERF-LC-Sq1	lung	COSMIC	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.1389
p.G1079V	H513	pleura	COSMIC	VPTPPPS	DEG_SCF_FBW7_1	1066:1072	Mutation rewiring degron network	0.1389

Kaplan plot for MED14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MED14

UniProt ID: O60244

Entrez ID: 9282

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MED14 in