DegronMD

Uniprot ID: O60244

Source protein: Mediator of RNA polymerase II transcription subunit 14

Source gene: MED14

Class: DEG_SCF_FBW7_1

Location: 1066:1072

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 77.2

COIL: 0.9614

CONS_SCORE: 0.2874

DSS_SCORE: 0.6274

HELIX: 0.012

FCONS_SCORE: 1.0145

RIG_SCORE: 0.5483

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1057W	TCGA-2L-AAQJ	PAAD	TCGA	VPTPPPS	DEG_SCF_FBW7_1	0.0833
p.L1057W	DO218949	PAAD	ICGC	VPTPPPS	DEG_SCF_FBW7_1	0.0833
p.I1078V	TCGA-5P-A9JY	KIRP	TCGA	VPTPPPS	DEG_SCF_FBW7_1	0.1667
p.I1078V	DO223944	KIRP	ICGC	VPTPPPS	DEG_SCF_FBW7_1	0.1667
p.A1063V	TCGA-BS-A0TJ	UCEC	TCGA	VPTPPPS	DEG_SCF_FBW7_1	0.25
p.A1063V	DO42953	UCEC	ICGC	VPTPPPS	DEG_SCF_FBW7_1	0.25
p.H1074R	TCGA-DD-AAVR	LIHC	TCGA	VPTPPPS	DEG_SCF_FBW7_1	0.2778
p.H1074R	DO52278	LIHC	ICGC	VPTPPPS	DEG_SCF_FBW7_1	0.2778
p.G1081W	TCGA-EE-A29G	SKCM	TCGA	VPTPPPS	DEG_SCF_FBW7_1	0.0833
p.G1081W	DO47303	SKCM	ICGC	VPTPPPS	DEG_SCF_FBW7_1	0.0833
p.A1082T	TCGA-EO-A22R	UCEC	TCGA	VPTPPPS	DEG_SCF_FBW7_1	0.0556
p.A1082T	DO42713	UCEC	ICGC	VPTPPPS	DEG_SCF_FBW7_1	0.0556
p.S1064L	DO52434	COCA	ICGC	VPTPPPS	DEG_SCF_FBW7_1	0.2778
p.T1068A	DO33091	PACA	ICGC	VPTPPPS	DEG_SCF_FBW7_1	0.7139
p.G1079V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VPTPPPS	DEG_SCF_FBW7_1	0.1389
p.G1079V	RERF-LC-Sq1	lung	COSMIC	VPTPPPS	DEG_SCF_FBW7_1	0.1389
p.G1079V	H513	pleura	COSMIC	VPTPPPS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60244	Mediator of RNA polymerase II transcription subunit 14	DEG_SCF_FBW7_1	1066:1072	VPTPPPS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons