DegronMD - Q6ZP82(CCDC141)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M1232V	TCGA-52-7809	LUSC	TCGA	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.1944
p.M1232V	DO26746	LUSC	ICGC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.1944
p.G1259V	TCGA-61-1899	OV	TCGA	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.2778
p.G1259V	DO28346	OV	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.2778
p.G1254W	TCGA-63-A5MW	LUSC	TCGA	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation altering degron motif	0.6714
p.G1254W	DO219169	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation altering degron motif	0.6714
p.V1265L	TCGA-A2-A0YJ	BRCA	TCGA	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1111
p.V1265L	DO3013	BRCA	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1111
p.K1348Q	TCGA-A5-A0G2	UCEC	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation altering degron motif	0.5833
p.K1348Q	DO41235	UCEC	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation altering degron motif	0.5833
p.A1228V	TCGA-A5-A1OF	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.0833
p.A1228V	DO42568	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.0833
p.E1263K	TCGA-AA-3977	COAD	TCGA	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1667
p.E1263K	TCGA-EE-A181	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1667
p.E1263K	TCGA-EE-A2MS	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1667
p.E1263K	DO8730	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1667
p.E1263K	DO37567	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1667
p.E1263K	DO37444	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1667
p.L1266I	TCGA-AA-A00N	COAD	TCGA	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.0833
p.L1266I	TCGA-AA-A010	COAD	TCGA	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.0833
p.L1266I	DO9876	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.0833
p.S1243G	TCGA-AG-3891	READ	TCGA	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.2778
p.S1243G	TCGA-AG-3891	READ	TCGA	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.0556
p.S1243G	DO36388	READ	ICGC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.2778
p.S1243G	DO36388	READ	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.0556
p.V1161G	TCGA-AP-A056	UCEC	TCGA	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation rewiring degron network	0.1389
p.V1161G	DO43971	UCEC	ICGC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation rewiring degron network	0.1389
p.K1142N	TCGA-AP-A1DV	UCEC	TCGA	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation substituting flanking lysine	0.2778
p.K1142N	DO43186	UCEC	ICGC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation substituting flanking lysine	0.2778
p.A1253D	TCGA-AX-A06F	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation altering degron motif	0.7793
p.A1253D	DO41752	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation altering degron motif	0.7793
p.P1237H	TCGA-AX-A06F	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation altering degron motif	0.7694
p.P1237H	DO41752	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation altering degron motif	0.7694
p.K1148N	TCGA-AX-A2HC	UCEC	TCGA	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation altering degron motif	0.6918
p.K1148N	DO41572	UCEC	ICGC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation altering degron motif	0.6918
p.S1241F	TCGA-D9-A6EC	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation altering degron motif	0.7982
p.S1241F	DO220851	MELA	ICGC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation altering degron motif	0.7982
p.S1241F	DO50291	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation altering degron motif	0.7982
p.G1250W	TCGA-DA-A960	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.0833
p.G1250W	TCGA-DA-A960	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.25
p.G1250W	DO219482	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.0833
p.G1250W	DO219482	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.25
p.Q1337H	TCGA-DF-A2KU	UCEC	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.0833
p.Q1337H	DO223286	UCEC	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.0833
p.E1235K	TCGA-EE-A29E	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.2778
p.E1235K	DO37831	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.2778
p.T1356N	TCGA-EE-A3AE	SKCM	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.2222
p.T1356N	DO37802	SKCM	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.2222
p.Q1339P	TCGA-EE-A3JB	SKCM	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.1389
p.Q1339P	DO51250	SKCM	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.1389
p.M1232I	TCGA-EK-A2RK	CESC	TCGA	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.1944
p.M1232I	DO49952	CESC	ICGC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.1944
p.T1358I	TCGA-FS-A4F5	SKCM	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.1667
p.T1358I	DO37881	SKCM	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.1667
p.D1352N	TCGA-QB-AA9O	SKCM	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation altering degron motif	0.6932
p.D1352N	DO51267	SKCM	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation altering degron motif	0.6932
p.S1230C	DO224844	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.1389
p.T1255S	DO50398	ESAD	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation altering degron motif	0.6005
p.N1354T	DO10842	ESAD	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.2778
p.H1350N	DO229022	LICA	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation altering degron motif	0.7423
p.Q1359K	DO229027	LICA	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation rewiring degron network	0.1389
p.H1245Y	DO220862	MELA	ICGC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.2222
p.H1245Y	DO220862	MELA	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.1111
p.D1260N	DO220912	MELA	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.25
p.D1260N	DO222868	MELA	ICGC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.25
p.A1145G	DO38404	STAD	ICGC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation rewiring degron network	0.25
p.P1144S	SIDM00422	Hodgkin's Lymphoma	GDSC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation rewiring degron network	0.2222
p.P1144S	ACH-001203	Lymphoma	CCLE	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation rewiring degron network	0.2222
p.P1144S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation rewiring degron network	0.2222
p.V1238F	SIDM00269	Ewing's Sarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation altering degron motif	0.5957
p.V1238F	ACH-002108	Bone Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation altering degron motif	0.5957
p.V1238F	ES7	bone	COSMIC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation altering degron motif	0.5957
p.E1347D	SIDM00193	Colorectal Carcinoma	GDSC	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation altering degron motif	0.5647
p.E1347D	SNU-81	large intestine	COSMIC	REKMHAD	LIG_APCC_ABBAyCdc20_2	1346:1352	Mutation altering degron motif	0.5647
p.A1261T	SIDM00852	Glioma	GDSC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.2222
p.A1261T	ACH-000389	Brain Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.2222
p.A1261T	H4	central nervous system	COSMIC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.2222
p.S1256R	SIDM00836	Colorectal Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation altering degron motif	0.7427
p.S1256R	ACH-000820	Colon/Colorectal Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation altering degron motif	0.7427
p.S1256R	SW403	large intestine	COSMIC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation altering degron motif	0.7427
p.E1143K	SIDM00006	Other Solid Cancers	GDSC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation rewiring degron network	0.1944
p.E1143K	ACH-001552	Skin Cancer	CCLE	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation rewiring degron network	0.1944
p.E1143K	MCC26	skin	COSMIC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	1148:1154	Mutation rewiring degron network	0.1944
p.G1250V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.0833
p.G1250V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.25
p.G1250V	ACH-000888	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.0833
p.G1250V	ACH-000888	Lung Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.25
p.G1250V	NCI-H1793	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.0833
p.G1250V	NCI-H1793	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.25
p.L1227I	SIDM00901	Endometrial Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.0556
p.L1227I	ACH-000940	Endometrial/Uterine Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.0556
p.L1227I	AN3-CA	endometrium	COSMIC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.0556
p.S1240F	SIDM00115	Head and Neck Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation altering degron motif	0.7982
p.S1240F	ACH-002298	Head and Neck Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation altering degron motif	0.7982
p.S1240F	PCI-6A	upper aerodigestive tract	COSMIC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation altering degron motif	0.7982
p.D1260Y	SIDM01611	Endometrial Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.25
p.V1251L	SIDM01590	Breast Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	1237:1241	Mutation rewiring degron network	0.0556
p.V1251L	SIDM01590	Breast Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	1253:1257	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC141

UniProt ID: Q6ZP82

Entrez ID: 285025

Protein name: Coiled-coil domain-containing protein 141 (Coiled-coil protein associated with myosin II and DISC1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC141 in