DegronMD

Uniprot ID: Q6ZP82

Source protein: Coiled-coil domain-containing protein 141

Source gene: CCDC141

Class: LIG_APCC_ABBAyCdc20_2

Location: 1346:1352

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8068

ASA_SCORE: 97.1

COIL: 0.5723

CONS_SCORE: 0

DSS_SCORE: 0.6361

HELIX: 0.071

FCONS_SCORE: 0

RIG_SCORE: 0.7179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1348Q	TCGA-A5-A0G2	UCEC	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.5833
p.K1348Q	DO41235	UCEC	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.5833
p.Q1337H	TCGA-DF-A2KU	UCEC	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q1337H	DO223286	UCEC	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.0833
p.T1356N	TCGA-EE-A3AE	SKCM	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T1356N	DO37802	SKCM	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q1339P	TCGA-EE-A3JB	SKCM	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q1339P	DO51250	SKCM	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.1389
p.T1358I	TCGA-FS-A4F5	SKCM	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T1358I	DO37881	SKCM	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D1352N	TCGA-QB-AA9O	SKCM	TCGA	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D1352N	DO51267	SKCM	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.6932
p.N1354T	DO10842	ESAD	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.2778
p.H1350N	DO229022	LICA	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.7423
p.Q1359K	DO229027	LICA	ICGC	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E1347D	SIDM00193	Colorectal Carcinoma	GDSC	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.5647
p.E1347D	SNU-81	large_intestine	COSMIC	REKMHAD	LIG_APCC_ABBAyCdc20_2	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZP82	Coiled-coil domain-containing protein 141	LIG_APCC_ABBAyCdc20_2	1346:1352	REKMHAD	APC,CDC20,FZR1	0.8068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons