DegronMD

Uniprot ID: Q6ZP82

Source protein: Coiled-coil domain-containing protein 141

Source gene: CCDC141

Class: LIG_APCC_ABBAyCdc20_2

Location: 1148:1154

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5444

ASA_SCORE: 97.5286

COIL: 0.4031

CONS_SCORE: 0

DSS_SCORE: 0.4974

HELIX: 0.5719

FCONS_SCORE: 0

RIG_SCORE: 0.8007

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1161G	TCGA-AP-A056	UCEC	TCGA	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V1161G	DO43971	UCEC	ICGC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.K1142N	TCGA-AP-A1DV	UCEC	TCGA	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K1142N	DO43186	UCEC	ICGC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K1148N	TCGA-AX-A2HC	UCEC	TCGA	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K1148N	DO41572	UCEC	ICGC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.6918
p.A1145G	DO38404	STAD	ICGC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.25
p.P1144S	SIDM00422	Hodgkin's Lymphoma	GDSC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P1144S	ACH-001203	Lymphoma	CCLE	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P1144S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E1143K	SIDM00006	Other Solid Cancers	GDSC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E1143K	ACH-001552	Skin Cancer	CCLE	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E1143K	MCC26	skin	COSMIC	KQTIFNE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZP82	Coiled-coil domain-containing protein 141	LIG_APCC_ABBAyCdc20_2	1148:1154	KQTIFNE	APC,CDC20,FZR1	0.5444	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons