DegronMD

Uniprot ID: Q6ZP82

Source protein: Coiled-coil domain-containing protein 141

Source gene: CCDC141

Class: DEG_SPOP_SBC_1

Location: 1253:1257

E3 ligase: SPOP

DEGRON score: 0.9861

ASA_SCORE: 67.56

COIL: 0.8706

CONS_SCORE: 0

DSS_SCORE: 0.5563

HELIX: 0.0232

FCONS_SCORE: 0

RIG_SCORE: 0.5762

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1259V	TCGA-61-1899	OV	TCGA	AGTSS	DEG_SPOP_SBC_1	0.2778
p.G1259V	DO28346	OV	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2778
p.G1254W	TCGA-63-A5MW	LUSC	TCGA	AGTSS	DEG_SPOP_SBC_1	0.6714
p.G1254W	DO219169	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.6714
p.V1265L	TCGA-A2-A0YJ	BRCA	TCGA	AGTSS	DEG_SPOP_SBC_1	0.1111
p.V1265L	DO3013	BRCA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1111
p.E1263K	TCGA-AA-3977	COAD	TCGA	AGTSS	DEG_SPOP_SBC_1	0.1667
p.E1263K	TCGA-EE-A181	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	0.1667
p.E1263K	TCGA-EE-A2MS	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	0.1667
p.E1263K	DO8730	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1667
p.E1263K	DO37567	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1667
p.E1263K	DO37444	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1667
p.L1266I	TCGA-AA-A00N	COAD	TCGA	AGTSS	DEG_SPOP_SBC_1	0.0833
p.L1266I	TCGA-AA-A010	COAD	TCGA	AGTSS	DEG_SPOP_SBC_1	0.0833
p.L1266I	DO9876	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.S1243G	TCGA-AG-3891	READ	TCGA	AGTSS	DEG_SPOP_SBC_1	0.0556
p.S1243G	DO36388	READ	ICGC	AGTSS	DEG_SPOP_SBC_1	0.0556
p.A1253D	TCGA-AX-A06F	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	0.7793
p.A1253D	DO41752	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.7793
p.G1250W	TCGA-DA-A960	SKCM	TCGA	AGTSS	DEG_SPOP_SBC_1	0.25
p.G1250W	DO219482	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.25
p.T1255S	DO50398	ESAD	ICGC	AGTSS	DEG_SPOP_SBC_1	0.6005
p.H1245Y	DO220862	MELA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1111
p.D1260N	DO220912	MELA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.25
p.D1260N	DO222868	MELA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.25
p.A1261T	SIDM00852	Glioma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.A1261T	ACH-000389	Brain Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	0.2222
p.A1261T	H4	central_nervous_system	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.S1256R	SIDM00836	Colorectal Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.7427
p.S1256R	ACH-000820	Colon/Colorectal Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	0.7427
p.S1256R	SW403	large_intestine	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.7427
p.G1250V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.25
p.G1250V	ACH-000888	Lung Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	0.25
p.G1250V	NCI-H1793	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.25
p.D1260Y	SIDM01611	Endometrial Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.25
p.V1251L	SIDM01590	Breast Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60244	Mediator of RNA polymerase II transcription subunit 14	DEG_SPOP_SBC_1	1147:1151	AGTSS	SPOP	0.9972	More...
O95073	Fibrinogen silencer-binding protein	DEG_SPOP_SBC_1	134:138	AGTSS	SPOP	0.9917	More...
O95249	Golgi SNAP receptor complex member 1	DEG_SPOP_SBC_1	3:7	AGTSS	SPOP	0.9984	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	265:269	AGTSS	SPOP	0.9527	More...
P82094	TATA element modulatory factor	DEG_SPOP_SBC_1	166:170	AGTSS	SPOP	0.9993	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	724:728	AGTSS	SPOP	0.999	More...
Q5VT06	Centrosome-associated protein 350	DEG_SPOP_SBC_1	1271:1275	AGTSS	SPOP	0.9877	More...
Q6ZP82	Coiled-coil domain-containing protein 141	DEG_SPOP_SBC_1	1253:1257	AGTSS	SPOP	0.9861	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3117:3121	AGTSS	SPOP	0.9982	More...
Q8TEH3	DENN domain-containing protein 1A	DEG_SPOP_SBC_1	775:779	AGTSS	SPOP	0.8732	More...
Q8WV16	DDB1- and CUL4-associated factor 4	DEG_SPOP_SBC_1	58:62	AGTSS	SPOP	0.9954	More...
Q99990	Transcription cofactor vestigial-like protein 1	DEG_SPOP_SBC_1	137:141	AGTSS	SPOP	0.8905	More...
Q9HCC9	Lateral signaling target protein 2 homolog	DEG_SPOP_SBC_1	474:478	AGTSS	SPOP	0.7998	More...
Q9HCR9	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	DEG_SPOP_SBC_1	56:60	AGTSS	SPOP	0.8678	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	197:201	AGTSS	SPOP	0.9517	More...
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1162:1166	AGTSS	SPOP	0.9841	More...
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	385:389	AGTSS	SPOP	0.9713	More...
Q9Y5A7	NEDD8 ultimate buster 1	DEG_SPOP_SBC_1	556:560	AGTSS	SPOP	0.9912	More...
Q5VWJ9	Sorting nexin-30	DEG_SPOP_SBC_1	63:67	AGTSS	SPOP	0.9979	More...
Q5JYT7	Uncharacterized protein KIAA1755	DEG_SPOP_SBC_1	294:298	AGTSS	SPOP	0.9974	More...
Q8N4B5	Proline-rich protein 18	DEG_SPOP_SBC_1	119:123	AGTSS	SPOP	0.9888	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	83:87	AGTSS	SPOP	0.9884	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGTSS

Degron related mutations and impact score

Drug responses associated with CCDC141 mutations

All proteins holding degron of AGTSS