DegronMD - Q8TEH3(DENND1A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G26V	TCGA-44-2656	LUAD	TCGA	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1111
p.G26V	DO26052	LUAD	ICGC	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1111
p.D780N	TCGA-44-2665	LUAD	TCGA	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.3056
p.D780N	DO23582	LUAD	ICGC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.3056
p.D780N	ACH-001802	Liposarcoma	CCLE	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.3056
p.A803T	TCGA-5M-AAT6	COAD	TCGA	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1389
p.A803T	DO223703	COAD	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1389
p.P818S	TCGA-78-7158	LUAD	TCGA	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.2778
p.P818S	DO24729	LUAD	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.2778
p.R701W	TCGA-BK-A13B	UCEC	TCGA	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.0833
p.R701W	DO40825	UCEC	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.0833
p.R701Q	TCGA-C5-A2LV	CESC	TCGA	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.0833
p.R701Q	DO48987	CESC	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.0833
p.R701Q	ACH-000961	Endometrial/Uterine Cancer	CCLE	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.0833
p.R801H	TCGA-CG-4460	STAD	TCGA	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.0833
p.R801H	DO38427	STAD	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.0833
p.L785F	TCGA-CW-6093	KIRC	TCGA	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1667
p.L785F	DO16248	KIRC	ICGC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1667
p.R677Q	TCGA-D1-A167	UCEC	TCGA	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.1389
p.R677Q	DO40978	UCEC	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.1389
p.R677L	TCGA-D3-A2JL	SKCM	TCGA	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.1389
p.R677L	DO47278	SKCM	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.1389
p.T777M	TCGA-DF-A2KU	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation altering degron motif	0.7423
p.T777M	DO228338	MALY	ICGC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation altering degron motif	0.7423
p.T777M	DO223286	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation altering degron motif	0.7423
p.P690T	TCGA-DF-A2KU	UCEC	TCGA	SDKEEVPTP	DEG_COP1_1	684:692	Mutation altering degron motif	0.7031
p.P690T	DO229024	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation altering degron motif	0.7031
p.P690T	DO229035	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation altering degron motif	0.7031
p.P690T	DO223286	UCEC	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation altering degron motif	0.7031
p.P700S	TCGA-EE-A181	SKCM	TCGA	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.1111
p.P700S	DO37444	SKCM	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.1111
p.P805T	TCGA-EE-A2M6	SKCM	TCGA	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1944
p.P805T	DO37976	SKCM	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1944
p.P702H	TCGA-EE-A2MN	SKCM	TCGA	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.0556
p.P702H	DO37423	SKCM	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.0556
p.Q675H	TCGA-EI-6917	READ	TCGA	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.0833
p.Q675H	DO36881	READ	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.0833
p.R677W	TCGA-EO-A22U	UCEC	TCGA	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.1389
p.R677W	DO43755	UCEC	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.1389
p.A20T	TCGA-FI-A2D5	UCEC	TCGA	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2778
p.P700L	TCGA-FS-A1ZK	SKCM	TCGA	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.1111
p.P700L	DO37474	SKCM	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.1111
p.P805Q	TCGA-GN-A265	SKCM	TCGA	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1944
p.P805Q	DO37491	SKCM	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1944
p.A11V	DO233762	GACA	ICGC	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2778
p.A784T	DO233889	GACA	ICGC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.T809A	DO233855	GACA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.3056
p.P702T	DO228948	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.0556
p.P674T	DO228978	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.0556
p.T693N	DO229029	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.3056
p.E688K	DO44680	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation altering degron motif	0.591
p.S696R	DO230961	LUSC	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.2222
p.S696R	DO224594	LUSC	ICGC	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.2222
p.P772L	DO220886	MELA	ICGC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.25
p.S3P	DO232826	NACA	ICGC	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.0556
p.T804P	DO229167	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1667
p.T804P	DO229103	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1667
p.A803P	DO229192	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1389
p.A803P	DO229103	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1389
p.Q814P	DO229195	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation altering degron motif	0.5924
p.T804I	DO229268	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1667
p.G26D	SIDM00683	Prostate Carcinoma	GDSC	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1111
p.G26D	ACH-000977	lymph node	CCLE	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1111
p.G26D	LNCaP-Clone-FGC	prostate	COSMIC	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1111
p.A784D	SIDM01096	Colorectal Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784D	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784D	SIDM00627	Cervical Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784D	SIDM01168	Colorectal Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784D	SIDM00265	Ewing's Sarcoma	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784D	SIDM00900	Non-Cancerous	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784D	SIDM00864	Cervical Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784D	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784D	SIDM00701	Non-Cancerous	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784D	SIDM01502	Endometrial Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784D	SIDM01323	Oral Cavity Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784S	SIDM01156	Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784S	ACH-000890	Lung Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.A784S	SW1271	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	775:779	Mutation rewiring degron network	0.1944
p.P802S	SIDM00185	Melanoma	GDSC	PFTPQFS	DEG_SCF_FBW7_1	810:816	Mutation rewiring degron network	0.1111
p.R23M	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1944
p.R23M	ACH-000021	Lung Cancer	CCLE	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1944
p.R23M	ACH-000033	Lung Cancer	CCLE	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1944
p.R23M	NCI-H1693	lung	COSMIC	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1944
p.I680M	ACH-000600	Kidney Cancer	CCLE	SDKEEVPTP	DEG_COP1_1	684:692	Mutation rewiring degron network	0.2222
p.P690L	ACH-002785	Unknown	CCLE	SDKEEVPTP	DEG_COP1_1	684:692	Mutation altering degron motif	0.7582
p.A11T	LNCaP-Clone-FGC	prostate	COSMIC	FEVYVE	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DENND1A

UniProt ID: Q8TEH3

Entrez ID: 57706

Protein name: DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DENND1A in