DegronMD

Uniprot ID: Q8TEH3

Source protein: DENN domain-containing protein 1A

Source gene: DENND1A

Class: DEG_COP1_1

Location: 684:692

E3 ligase: COP1

DEGRON score: 0.5023

ASA_SCORE: 92.3333

COIL: 0.9081

CONS_SCORE: 0.2467

DSS_SCORE: 0.6938

HELIX: 0.063

FCONS_SCORE: 0.825

RIG_SCORE: 0.6439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R701W	TCGA-BK-A13B	UCEC	TCGA	SDKEEVPTP	DEG_COP1_1	0.0833
p.R701W	DO40825	UCEC	ICGC	SDKEEVPTP	DEG_COP1_1	0.0833
p.R701Q	TCGA-C5-A2LV	CESC	TCGA	SDKEEVPTP	DEG_COP1_1	0.0833
p.R701Q	DO48987	CESC	ICGC	SDKEEVPTP	DEG_COP1_1	0.0833
p.R701Q	ACH-000961	Endometrial/Uterine Cancer	CCLE	SDKEEVPTP	DEG_COP1_1	0.0833
p.R677Q	TCGA-D1-A167	UCEC	TCGA	SDKEEVPTP	DEG_COP1_1	0.1389
p.R677Q	DO40978	UCEC	ICGC	SDKEEVPTP	DEG_COP1_1	0.1389
p.R677L	TCGA-D3-A2JL	SKCM	TCGA	SDKEEVPTP	DEG_COP1_1	0.1389
p.R677L	DO47278	SKCM	ICGC	SDKEEVPTP	DEG_COP1_1	0.1389
p.P690T	TCGA-DF-A2KU	UCEC	TCGA	SDKEEVPTP	DEG_COP1_1	0.7031
p.P690T	DO229024	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	0.7031
p.P690T	DO229035	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	0.7031
p.P690T	DO223286	UCEC	ICGC	SDKEEVPTP	DEG_COP1_1	0.7031
p.P700S	TCGA-EE-A181	SKCM	TCGA	SDKEEVPTP	DEG_COP1_1	0.1111
p.P700S	DO37444	SKCM	ICGC	SDKEEVPTP	DEG_COP1_1	0.1111
p.P702H	TCGA-EE-A2MN	SKCM	TCGA	SDKEEVPTP	DEG_COP1_1	0.0556
p.P702H	DO37423	SKCM	ICGC	SDKEEVPTP	DEG_COP1_1	0.0556
p.Q675H	TCGA-EI-6917	READ	TCGA	SDKEEVPTP	DEG_COP1_1	0.0833
p.Q675H	DO36881	READ	ICGC	SDKEEVPTP	DEG_COP1_1	0.0833
p.R677W	TCGA-EO-A22U	UCEC	TCGA	SDKEEVPTP	DEG_COP1_1	0.1389
p.R677W	DO43755	UCEC	ICGC	SDKEEVPTP	DEG_COP1_1	0.1389
p.P700L	TCGA-FS-A1ZK	SKCM	TCGA	SDKEEVPTP	DEG_COP1_1	0.1111
p.P700L	DO37474	SKCM	ICGC	SDKEEVPTP	DEG_COP1_1	0.1111
p.P702T	DO228948	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	0.0556
p.P674T	DO228978	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	0.0556
p.T693N	DO229029	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	0.3056
p.E688K	DO44680	LICA	ICGC	SDKEEVPTP	DEG_COP1_1	0.591
p.S696R	DO230961	LUSC	ICGC	SDKEEVPTP	DEG_COP1_1	0.2222
p.S696R	DO224594	LUSC	ICGC	SDKEEVPTP	DEG_COP1_1	0.2222
p.I680M	ACH-000600	Kidney Cancer	CCLE	SDKEEVPTP	DEG_COP1_1	0.2222
p.P690L	ACH-002785	Unknown	CCLE	SDKEEVPTP	DEG_COP1_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEH3	DENN domain-containing protein 1A	DEG_COP1_1	684:692	SDKEEVPTP	COP1	0.5023	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SDKEEVPTP

Degron related mutations and impact score

Drug responses associated with DENND1A mutations

All proteins holding degron of SDKEEVPTP