DegronMD

Uniprot ID: Q8TEH3

Source protein: DENN domain-containing protein 1A

Source gene: DENND1A

Class: LIG_APCC_ABBA_1

Location: 13:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5168

ASA_SCORE: 14.9667

COIL: 0.0605

CONS_SCORE: 0.517

DSS_SCORE: 0.4255

HELIX: 0.024

FCONS_SCORE: 1.3669

RIG_SCORE: 0.8712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G26V	TCGA-44-2656	LUAD	TCGA	FEVYVE	LIG_APCC_ABBA_1	0.1111
p.G26V	DO26052	LUAD	ICGC	FEVYVE	LIG_APCC_ABBA_1	0.1111
p.A20T	TCGA-FI-A2D5	UCEC	TCGA	FEVYVE	LIG_APCC_ABBA_1	0.2778
p.A11V	DO233762	GACA	ICGC	FEVYVE	LIG_APCC_ABBA_1	0.2778
p.S3P	DO232826	NACA	ICGC	FEVYVE	LIG_APCC_ABBA_1	0.0556
p.G26D	SIDM00683	Prostate Carcinoma	GDSC	FEVYVE	LIG_APCC_ABBA_1	0.1111
p.G26D	ACH-000977	lymph_node	CCLE	FEVYVE	LIG_APCC_ABBA_1	0.1111
p.G26D	LNCaP-Clone-FGC	prostate	COSMIC	FEVYVE	LIG_APCC_ABBA_1	0.1111
p.R23M	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	FEVYVE	LIG_APCC_ABBA_1	0.1944
p.R23M	ACH-000021	Lung Cancer	CCLE	FEVYVE	LIG_APCC_ABBA_1	0.1944
p.R23M	ACH-000033	Lung Cancer	CCLE	FEVYVE	LIG_APCC_ABBA_1	0.1944
p.R23M	NCI-H1693	lung	COSMIC	FEVYVE	LIG_APCC_ABBA_1	0.1944
p.A11T	LNCaP-Clone-FGC	prostate	COSMIC	FEVYVE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEH3	DENN domain-containing protein 1A	LIG_APCC_ABBA_1	13:18	FEVYVE	APC,CDC20,FZR1	0.5168	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons