DegronMD

Uniprot ID: Q8TEH3

Source protein: DENN domain-containing protein 1A

Source gene: DENND1A

Class: DEG_SCF_FBW7_1

Location: 810:816

E3 ligase: FBXW7

DEGRON score: 0.9229

ASA_SCORE: 88.3286

COIL: 0.933

CONS_SCORE: 0.2724

DSS_SCORE: 0.5723

HELIX: 0.0439

FCONS_SCORE: 0.8103

RIG_SCORE: 0.6922

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A803T	TCGA-5M-AAT6	COAD	TCGA	PFTPQFS	DEG_SCF_FBW7_1	0.1389
p.A803T	DO223703	COAD	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.1389
p.P818S	TCGA-78-7158	LUAD	TCGA	PFTPQFS	DEG_SCF_FBW7_1	0.2778
p.P818S	DO24729	LUAD	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.2778
p.R801H	TCGA-CG-4460	STAD	TCGA	PFTPQFS	DEG_SCF_FBW7_1	0.0833
p.R801H	DO38427	STAD	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.0833
p.P805T	TCGA-EE-A2M6	SKCM	TCGA	PFTPQFS	DEG_SCF_FBW7_1	0.1944
p.P805T	DO37976	SKCM	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.1944
p.P805Q	TCGA-GN-A265	SKCM	TCGA	PFTPQFS	DEG_SCF_FBW7_1	0.1944
p.P805Q	DO37491	SKCM	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.1944
p.T809A	DO233855	GACA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.3056
p.T804P	DO229167	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.1667
p.T804P	DO229103	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.1667
p.A803P	DO229192	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.1389
p.A803P	DO229103	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.1389
p.Q814P	DO229195	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.5924
p.T804I	DO229268	THCA	ICGC	PFTPQFS	DEG_SCF_FBW7_1	0.1667
p.P802S	SIDM00185	Melanoma	GDSC	PFTPQFS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEH3	DENN domain-containing protein 1A	DEG_SCF_FBW7_1	810:816	PFTPQFS	FBXW7	0.9229	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons