DegronMD - Q9HCR9(PDE11A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A62V	TCGA-BL-A5ZZ	BLCA	TCGA	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2778
p.A62V	DO44027	BLCA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2778
p.S64I	TCGA-DU-6392	LGG	TCGA	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.S64I	TCGA-EO-A3B0	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.S64I	DO22237	LGG	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.S64I	DO219773	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.A62T	TCGA-FD-A3SR	BLCA	TCGA	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2778
p.A62T	DO810	BLCA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2778
p.R64C	DO6112	BRCA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.R64C	DO230342	COCA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.R64C	DO43306	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.R66I	DO9956	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1667
p.D63N	DO8530	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.25
p.D63N	DO10880	GBM	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.25
p.Y48C	DO8264	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1111
p.T51I	DO234285	ESAD	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1944
p.T58A	DO233652	GACA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.7139
p.P51L	DO219107	GBM	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1944
p.P51L	TALL-1	haematopoietic and lymphoid tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1944
p.P51L	BALL-1	haematopoietic and lymphoid tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1944
p.P51L	MEG-01	haematopoietic and lymphoid tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1944
p.P51L	NCCIT	testis	COSMIC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1944
p.P51L	CMK	haematopoietic and lymphoid tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1944
p.T65N	DO229026	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1944
p.A62D	DO229038	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2778
p.L60M	DO229037	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.711
p.D55G	DO229047	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.3056
p.T53K	DO229053	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.25
p.A47D	DO229009	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.A47D	DO26886	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.R66G	DO45317	LUAD	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1667
p.K69N	DO24790	LUAD	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.Y48F	DO23590	LUAD	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1111
p.D60N	DO230538	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.6932
p.D60N	DO37941	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.6932
p.I47K	DO26981	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.R57L	DO26993	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.8428
p.G67A	DO27334	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1389
p.R56Q	DO30420	OV	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.7329
p.L46R	DO36556	READ	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0556
p.I62L	DO36556	READ	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2778
p.V68G	DO229502	SKCA	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1111
p.F58L	DO37802	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.6981
p.G62C	DO37707	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2778
p.G62C	DO38033	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2778
p.Q59K	DO50279	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.6944
p.P51S	DO47700	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1944
p.D50V	DO38022	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1667
p.S61C	DO43162	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.3056
p.L69I	DO41903	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0833
p.R55W	DO41235	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.3056
p.D50N	DO43811	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1667
p.R52T	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.R52T	SIDM01203	Other Solid Cancers	GDSC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.R52T	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.R52T	SIDM00482	Chronic Myelogenous Leukemia	GDSC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.R52T	SIDM00050	Chondrosarcoma	GDSC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.R52T	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.R52T	SIDM00123	Kidney Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.R52T	SIDM01059	Melanoma	GDSC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.2222
p.A55S	COR-L95	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.3056
p.V68L	TMK-1	stomach	COSMIC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1111
p.S67F	COR-L95	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1389
p.V68F	COR-L95	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1111
p.E56Q	A253	salivary gland	COSMIC	AGTSS	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.6744

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDE11A

UniProt ID: Q9HCR9

Entrez ID: 50940

Protein name: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDE11A in