DegronMD

Uniprot ID: Q9HCR9

Source protein: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Source gene: PDE11A

Class: DEG_SPOP_SBC_1

Location: 56:60

E3 ligase: SPOP

DEGRON score: 0.8678

ASA_SCORE: 63.58

COIL: 0.7892

CONS_SCORE: 0.2514

DSS_SCORE: 0.589

HELIX: 0.1404

FCONS_SCORE: 0.9383

RIG_SCORE: 0.6213

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A62V	TCGA-BL-A5ZZ	BLCA	TCGA	AGTSS	DEG_SPOP_SBC_1	0.2778
p.A62V	DO44027	BLCA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2778
p.S64I	TCGA-DU-6392	LGG	TCGA	AGTSS	DEG_SPOP_SBC_1	0.2222
p.S64I	TCGA-EO-A3B0	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	0.2222
p.S64I	DO22237	LGG	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.S64I	DO219773	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.A62T	TCGA-FD-A3SR	BLCA	TCGA	AGTSS	DEG_SPOP_SBC_1	0.2778
p.A62T	DO810	BLCA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2778
p.R64C	DO6112	BRCA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.R64C	DO230342	COCA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.R64C	DO43306	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.R66I	DO9956	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1667
p.D63N	DO8530	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	0.25
p.D63N	DO10880	GBM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.25
p.Y48C	DO8264	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1111
p.T51I	DO234285	ESAD	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.T58A	DO233652	GACA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.7139
p.P51L	DO219107	GBM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.P51L	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.P51L	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.P51L	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.P51L	NCCIT	testis	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.P51L	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.T65N	DO229026	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.A62D	DO229038	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2778
p.L60M	DO229037	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.711
p.D55G	DO229047	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.3056
p.T53K	DO229053	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.25
p.A47D	DO229009	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.A47D	DO26886	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.R66G	DO45317	LUAD	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1667
p.K69N	DO24790	LUAD	ICGC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.Y48F	DO23590	LUAD	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1111
p.D60N	DO230538	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.6932
p.D60N	DO37941	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.6932
p.I47K	DO26981	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.R57L	DO26993	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.8428
p.G67A	DO27334	LUSC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1389
p.R56Q	DO30420	OV	ICGC	AGTSS	DEG_SPOP_SBC_1	0.7329
p.L46R	DO36556	READ	ICGC	AGTSS	DEG_SPOP_SBC_1	0.0556
p.I62L	DO36556	READ	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2778
p.V68G	DO229502	SKCA	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1111
p.F58L	DO37802	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.6981
p.G62C	DO37707	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2778
p.G62C	DO38033	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.2778
p.Q59K	DO50279	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.6944
p.P51S	DO47700	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1944
p.D50V	DO38022	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1667
p.S61C	DO43162	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.3056
p.L69I	DO41903	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.0833
p.R55W	DO41235	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.3056
p.D50N	DO43811	UCEC	ICGC	AGTSS	DEG_SPOP_SBC_1	0.1667
p.R52T	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.R52T	SIDM01203	Other Solid Cancers	GDSC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.R52T	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.R52T	SIDM00482	Chronic Myelogenous Leukemia	GDSC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.R52T	SIDM00050	Chondrosarcoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.R52T	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.R52T	SIDM00123	Kidney Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.R52T	SIDM01059	Melanoma	GDSC	AGTSS	DEG_SPOP_SBC_1	0.2222
p.A55S	COR-L95	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.3056
p.V68L	TMK-1	stomach	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.1111
p.S67F	COR-L95	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.1389
p.V68F	COR-L95	lung	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.1111
p.E56Q	A253	salivary_gland	COSMIC	AGTSS	DEG_SPOP_SBC_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60244	Mediator of RNA polymerase II transcription subunit 14	DEG_SPOP_SBC_1	1147:1151	AGTSS	SPOP	0.9972	More...
O95073	Fibrinogen silencer-binding protein	DEG_SPOP_SBC_1	134:138	AGTSS	SPOP	0.9917	More...
O95249	Golgi SNAP receptor complex member 1	DEG_SPOP_SBC_1	3:7	AGTSS	SPOP	0.9984	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	265:269	AGTSS	SPOP	0.9527	More...
P82094	TATA element modulatory factor	DEG_SPOP_SBC_1	166:170	AGTSS	SPOP	0.9993	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	724:728	AGTSS	SPOP	0.999	More...
Q5VT06	Centrosome-associated protein 350	DEG_SPOP_SBC_1	1271:1275	AGTSS	SPOP	0.9877	More...
Q6ZP82	Coiled-coil domain-containing protein 141	DEG_SPOP_SBC_1	1253:1257	AGTSS	SPOP	0.9861	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3117:3121	AGTSS	SPOP	0.9982	More...
Q8TEH3	DENN domain-containing protein 1A	DEG_SPOP_SBC_1	775:779	AGTSS	SPOP	0.8732	More...
Q8WV16	DDB1- and CUL4-associated factor 4	DEG_SPOP_SBC_1	58:62	AGTSS	SPOP	0.9954	More...
Q99990	Transcription cofactor vestigial-like protein 1	DEG_SPOP_SBC_1	137:141	AGTSS	SPOP	0.8905	More...
Q9HCC9	Lateral signaling target protein 2 homolog	DEG_SPOP_SBC_1	474:478	AGTSS	SPOP	0.7998	More...
Q9HCR9	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	DEG_SPOP_SBC_1	56:60	AGTSS	SPOP	0.8678	More...
Q9P0V3	SH3 domain-binding protein 4	DEG_SPOP_SBC_1	197:201	AGTSS	SPOP	0.9517	More...
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1162:1166	AGTSS	SPOP	0.9841	More...
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	385:389	AGTSS	SPOP	0.9713	More...
Q9Y5A7	NEDD8 ultimate buster 1	DEG_SPOP_SBC_1	556:560	AGTSS	SPOP	0.9912	More...
Q5VWJ9	Sorting nexin-30	DEG_SPOP_SBC_1	63:67	AGTSS	SPOP	0.9979	More...
Q5JYT7	Uncharacterized protein KIAA1755	DEG_SPOP_SBC_1	294:298	AGTSS	SPOP	0.9974	More...
Q8N4B5	Proline-rich protein 18	DEG_SPOP_SBC_1	119:123	AGTSS	SPOP	0.9888	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	83:87	AGTSS	SPOP	0.9884	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGTSS

Degron related mutations and impact score

Drug responses associated with PDE11A mutations

All proteins holding degron of AGTSS