DegronMD - Q03164(KMT2A)

FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L3784M	TCGA-06-5416	GBM	TCGA	PPEY	ITCH	3788:3791	Mutation blocking ubiquitination signal	0.6667
p.L3344F	TCGA-10-0930	OV	TCGA	ASSSS	DEG_SPOP_SBC_1	3335:3339	Mutation rewiring degron network	0.1944
p.K254N	TCGA-19-5956	GBM	TCGA	IKRTPSAT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.2778
p.K254N	DO13863	GBM	ICGC	IKRTPSAT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.2778
p.S3323N	TCGA-29-1771	OV	TCGA	AGTST	DEG_SPOP_SBC_1	3314:3318	Mutation rewiring degron network	0.1944
p.D920Y	TCGA-35-4122	LUAD	TCGA	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.3056
p.D920Y	DO23782	LUAD	ICGC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.3056
p.R3789C	TCGA-36-2543	OV	TCGA	PPEY	ITCH	3788:3791	Mutation altering degron motif	0.8301
p.R3789C	TCGA-EK-A3GK	CESC	TCGA	PPEY	ITCH	3788:3791	Mutation altering degron motif	0.8301
p.R2811C	TCGA-44-A4SS	LUAD	TCGA	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation altering degron motif	0.8301
p.S775F	TCGA-4B-A93V	LUAD	TCGA	PLTPPSS	DEG_SCF_FBW7_1	769:775	Mutation altering degron motif	0.7982
p.S775F	DO218926	LUAD	ICGC	PLTPPSS	DEG_SCF_FBW7_1	769:775	Mutation altering degron motif	0.7982
p.S98L	TCGA-53-7624	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.S98L	DO25058	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.D3779H	TCGA-53-7624	LUAD	TCGA	PPEY	ITCH	3788:3791	Mutation rewiring degron network	0.0833
p.R3789H	TCGA-63-A5MP	LUSC	TCGA	PPEY	ITCH	3788:3791	Mutation altering degron motif	0.8244
p.S2872L	TCGA-A2-A0EY	BRCA	TCGA	PESSS	DEG_SPOP_SBC_1	2867:2871	Mutation blocking phosphorylation signal	0.75
p.T3326I	TCGA-A5-A0G2	UCEC	TCGA	AGTST	DEG_SPOP_SBC_1	3314:3318	Mutation rewiring degron network	0.1111
p.T3326I	TCGA-A5-A0G2	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	3335:3339	Mutation rewiring degron network	0.0833
p.V3347I	TCGA-A5-A2K3	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	3335:3339	Mutation rewiring degron network	0.1111
p.S3253Y	TCGA-A5-A2K5	UCEC	TCGA	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation altering degron motif	0.712
p.S3253Y	TCGA-AP-A1E0	UCEC	TCGA	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation altering degron motif	0.712
p.S98P	TCGA-A6-6780	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.S98P	DO10244	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.R736M	TCGA-AG-A002	READ	TCGA	AGTSS	DEG_SPOP_SBC_1	724:728	Mutation rewiring degron network	0.1111
p.P3243H	TCGA-AJ-A3EL	UCEC	TCGA	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation altering degron motif	0.7694
p.K246N	TCGA-AP-A051	UCEC	TCGA	IKRTPSAT	DEG_SCF_FBW7_1	256:263	Mutation substituting flanking lysine	0.1667
p.K246N	DO42673	UCEC	ICGC	IKRTPSAT	DEG_SCF_FBW7_1	256:263	Mutation substituting flanking lysine	0.1667
p.K3233N	TCGA-AX-A06F	UCEC	TCGA	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation substituting flanking lysine	0.1667
p.K254Q	TCGA-AX-A0J0	UCEC	TCGA	IKRTPSAT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.2778
p.K254Q	DO41133	UCEC	ICGC	IKRTPSAT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.2778
p.S2816N	TCGA-AX-A1CE	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.2778
p.R2812I	TCGA-AX-A2HC	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation altering degron motif	0.8102
p.R2811H	TCGA-AX-A2HD	UCEC	TCGA	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation altering degron motif	0.8244
p.T953A	TCGA-B5-A1MX	UCEC	TCGA	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.1389
p.T953A	DO41999	UCEC	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.1389
p.V3334A	TCGA-B5-A3FC	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	3335:3339	Mutation rewiring degron network	0.3056
p.M2216V	TCGA-BR-4184	STAD	TCGA	QRSKLRIMS	DEG_APCC_DBOX_1	2203:2211	Mutation rewiring degron network	0.1944
p.P2818L	TCGA-BR-8590	STAD	TCGA	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation substituting flanking lysine	0.3333
p.S1002C	TCGA-C8-A27B	BRCA	TCGA	LSTPSSS	DEG_SCF_FBW7_1	991:997	Mutation rewiring degron network	0.1944
p.S1002C	TCGA-C8-A27B	BRCA	TCGA	PSSST	DEG_SPOP_SBC_1	994:998	Mutation rewiring degron network	0.2222
p.S1002C	DO4623	BRCA	ICGC	LSTPSSS	DEG_SCF_FBW7_1	991:997	Mutation rewiring degron network	0.1944
p.S1002C	DO4623	BRCA	ICGC	PSSST	DEG_SPOP_SBC_1	994:998	Mutation rewiring degron network	0.2222
p.D920H	TCGA-CN-A6V1	HNSC	TCGA	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.3056
p.D920H	DO52048	HNSC	ICGC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.3056
p.T2815K	TCGA-CZ-4865	KIRC	TCGA	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.3056
p.S936Y	TCGA-D1-A16X	UCEC	TCGA	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.2222
p.S936Y	DO41799	UCEC	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.2222
p.P837S	TCGA-D3-A51T	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.1389
p.P837S	DO47389	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.1389
p.S938L	TCGA-D9-A3Z1	SKCM	TCGA	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.2778
p.S938L	DO38105	SKCM	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.2778
p.N2751S	TCGA-DI-A1BU	UCEC	TCGA	GKENG	DEG_APCC_KENBOX_2	2745:2749	Mutation rewiring degron network	0.2778
p.L950I	TCGA-ER-A19G	SKCM	TCGA	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.2222
p.L950I	DO47284	SKCM	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.2222
p.P2151L	TCGA-FA-A82F	DLBC	TCGA	IRTPSYS	DEG_SCF_FBW7_1	2145:2151	Mutation altering degron motif	0.7582
p.P2151S	TCGA-FW-A3R5	SKCM	TCGA	IRTPSYS	DEG_SCF_FBW7_1	2145:2151	Mutation altering degron motif	0.6752
p.S996F	TCGA-FW-A5DX	SKCM	TCGA	LSTPSSS	DEG_SCF_FBW7_1	991:997	Mutation altering degron motif	0.6871
p.S996F	TCGA-FW-A5DX	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	994:998	Mutation altering degron motif	0.7982
p.S996F	DO47253	SKCM	ICGC	LSTPSSS	DEG_SCF_FBW7_1	991:997	Mutation altering degron motif	0.6871
p.S996F	DO47253	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	994:998	Mutation altering degron motif	0.7982
p.S261F	TCGA-GC-A6I1	BLCA	TCGA	IKRTPSAT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.7982
p.S261F	DO49770	BLCA	ICGC	IKRTPSAT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.7982
p.L3784V	TCGA-GL-A9DE	KIRP	TCGA	PPEY	ITCH	3788:3791	Mutation blocking ubiquitination signal	0.6667
p.S2819C	TCGA-IG-A3Y9	ESCA	TCGA	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.1944
p.S728F	TCGA-K4-A4AB	BLCA	TCGA	AGTSS	DEG_SPOP_SBC_1	724:728	Mutation altering degron motif	0.9093
p.S728F	DO44039	BLCA	ICGC	AGTSS	DEG_SPOP_SBC_1	724:728	Mutation altering degron motif	0.9093
p.R2746T	TCGA-PK-A5HC	ACC	TCGA	GKENG	DEG_APCC_KENBOX_2	2745:2749	Mutation altering degron motif	0.7876
p.S94L	TCGA-UT-A88E	MESO	TCGA	AASSS	DEG_SPOP_SBC_1	83:87	Mutation blocking phosphorylation signal	0.5833
p.S94L	TCGA-UT-A88E	MESO	TCGA	ASSSS	DEG_SPOP_SBC_1	89:93	Mutation blocking phosphorylation signal	0.75
p.S3240C	TCGA-XF-A9T8	BLCA	TCGA	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation rewiring degron network	0.25
p.S3240C	TCGA-XF-A9T8	BLCA	TCGA	APSST	DEG_SPOP_SBC_1	3235:3239	Mutation rewiring degron network	0.3056
p.S3239L	DO49760	BLCA	ICGC	APSST	DEG_SPOP_SBC_1	3235:3239	Mutation altering degron motif	0.7667
p.P3225A	DO49795	BLCA	ICGC	APSST	DEG_SPOP_SBC_1	3235:3239	Mutation rewiring degron network	0.0556
p.S2747C	DO49795	BLCA	ICGC	GKENG	DEG_APCC_KENBOX_2	2745:2749	Mutation altering degron motif	0.7541
p.D2802N	DO447	BLCA	ICGC	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.1111
p.D2801N	DO695	BLCA	ICGC	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.0833
p.S2869L	DO3614	BRCA	ICGC	PESSS	DEG_SPOP_SBC_1	2867:2871	Mutation altering degron motif	0.7667
p.S3339L	DO2401	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	3335:3339	Mutation altering degron motif	0.7667
p.S3789C	DO222656	BTCA	ICGC	PPEY	ITCH	3788:3791	Mutation altering degron motif	0.7541
p.R933W	DO222955	BTCA	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.1389
p.R933W	DO222955	BTCA	ICGC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1111
p.R933W	SIDM00395	Neuroblastoma	GDSC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.1389
p.R933W	SIDM00395	Neuroblastoma	GDSC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1111
p.R933W	ACH-000099	Neuroblastoma	CCLE	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.1389
p.R933W	ACH-000099	Neuroblastoma	CCLE	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1111
p.R933W	SIMA	autonomic ganglia	COSMIC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.1389
p.R933W	SIMA	autonomic ganglia	COSMIC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1111
p.A3318V	DO219724	CESC	ICGC	AGTST	DEG_SPOP_SBC_1	3314:3318	Mutation altering degron motif	0.6936
p.A3318V	DO10758	COAD	ICGC	AGTST	DEG_SPOP_SBC_1	3314:3318	Mutation altering degron motif	0.6936
p.A3318V	DO51766	STAD	ICGC	AGTST	DEG_SPOP_SBC_1	3314:3318	Mutation altering degron motif	0.6936
p.P3245H	DO219758	CESC	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation altering degron motif	0.7694
p.R3781H	DO9114	COAD	ICGC	PPEY	ITCH	3788:3791	Mutation rewiring degron network	0.1389
p.R3250I	DO7801	COAD	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation altering degron motif	0.8102
p.R3250I	DO222798	COCA	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation altering degron motif	0.8102
p.R2221G	DO8487	COAD	ICGC	QRSKLRIMS	DEG_APCC_DBOX_1	2203:2211	Mutation rewiring degron network	0.0556
p.T3238N	DO222755	COCA	ICGC	APSST	DEG_SPOP_SBC_1	3235:3239	Mutation altering degron motif	0.7055
p.F3782S	DO222884	COCA	ICGC	PPEY	ITCH	3788:3791	Mutation rewiring degron network	0.1667
p.S830R	DO234204	ESAD	ICGC	PFSSS	DEG_SPOP_SBC_1	826:830	Mutation altering degron motif	0.7427
p.R3242Q	DO234239	ESAD	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation rewiring degron network	0.3056
p.R3242Q	DO234239	ESAD	ICGC	APSST	DEG_SPOP_SBC_1	3235:3239	Mutation rewiring degron network	0.25
p.I256N	DO234230	ESAD	ICGC	IKRTPSAT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.728
p.I256N	RPMI-2650	upper aerodigestive tract	COSMIC	IKRTPSAT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.728
p.R2194H	DO223044	ESCA	ICGC	QRSKLRIMS	DEG_APCC_DBOX_1	2203:2211	Mutation rewiring degron network	0.0833
p.G951W	DO233641	GACA	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.1944
p.S763T	DO233796	GACA	ICGC	PLTPPSS	DEG_SCF_FBW7_1	769:775	Mutation rewiring degron network	0.1667
p.R3783W	DO233732	GACA	ICGC	PPEY	ITCH	3788:3791	Mutation rewiring degron network	0.1944
p.P2211S	DO49035	HNSC	ICGC	QRSKLRIMS	DEG_APCC_DBOX_1	2203:2211	Mutation altering degron motif	0.6752
p.W838C	DO228948	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.1111
p.V917F	DO228952	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.R3797S	DO228952	LICA	ICGC	PPEY	ITCH	3788:3791	Mutation rewiring degron network	0.1667
p.C2803F	DO229019	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.1389
p.S821I	DO229026	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.1944
p.A724S	DO229036	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	724:728	Mutation altering degron motif	0.7588
p.A724S	SIDM00845	Burkitt's Lymphoma	GDSC	AGTSS	DEG_SPOP_SBC_1	724:728	Mutation altering degron motif	0.7588
p.A2202S	DO229035	LICA	ICGC	QRSKLRIMS	DEG_APCC_DBOX_1	2203:2211	Mutation rewiring degron network	0.3056
p.A3261S	DO229041	LICA	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation rewiring degron network	0.1389
p.D2801G	DO229054	LICA	ICGC	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.0833
p.A955T	DO50912	LICA	ICGC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.0833
p.V3306I	DO230953	LUSC	ICGC	AGTST	DEG_SPOP_SBC_1	3314:3318	Mutation rewiring degron network	0.1111
p.V3306I	DO224624	LUSC	ICGC	AGTST	DEG_SPOP_SBC_1	3314:3318	Mutation rewiring degron network	0.1111
p.V3306I	DO43899	UCEC	ICGC	AGTST	DEG_SPOP_SBC_1	3314:3318	Mutation rewiring degron network	0.1111
p.T3334S	DO26419	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	3335:3339	Mutation rewiring degron network	0.3056
p.D2802Y	DO219189	LUSC	ICGC	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.1111
p.S912F	DO220872	MELA	ICGC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation blocking phosphorylation signal	0.5278
p.S912F	SIDM00545	Melanoma	GDSC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation blocking phosphorylation signal	0.5278
p.S912F	ACH-000987	Skin Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	921:925	Mutation blocking phosphorylation signal	0.5278
p.S912F	Mewo	skin	COSMIC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation blocking phosphorylation signal	0.5278
p.A3261T	DO33091	PACA	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation rewiring degron network	0.1389
p.T2857N	DO232224	PBCA	ICGC	PESSS	DEG_SPOP_SBC_1	2867:2871	Mutation rewiring degron network	0.0556
p.F3258L	DO36394	READ	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation rewiring degron network	0.2222
p.R2160Q	DO36556	READ	ICGC	IRTPSYS	DEG_SCF_FBW7_1	2145:2151	Mutation rewiring degron network	0.0833
p.R2160Q	DO41331	UCEC	ICGC	IRTPSYS	DEG_SCF_FBW7_1	2145:2151	Mutation rewiring degron network	0.0833
p.H3227Y	DO229446	SKCA	ICGC	APSST	DEG_SPOP_SBC_1	3235:3239	Mutation rewiring degron network	0.1111
p.S1004F	DO229456	SKCA	ICGC	LSTPSSS	DEG_SCF_FBW7_1	991:997	Mutation blocking phosphorylation signal	0.5833
p.S1004F	DO229456	SKCA	ICGC	PSSST	DEG_SPOP_SBC_1	994:998	Mutation blocking phosphorylation signal	0.6111
p.P2808H	DO37406	SKCM	ICGC	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.2778
p.S2876F	DO47625	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	2867:2871	Mutation rewiring degron network	0.1944
p.P3228S	DO51301	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	3235:3239	Mutation rewiring degron network	0.1389
p.R3783Q	DO47973	STAD	ICGC	PPEY	ITCH	3788:3791	Mutation rewiring degron network	0.1944
p.P2868H	DO222328	STAD	ICGC	PESSS	DEG_SPOP_SBC_1	2867:2871	Mutation altering degron motif	0.7694
p.K2741E	DO38909	THCA	ICGC	GKENG	DEG_APCC_KENBOX_2	2745:2749	Mutation rewiring degron network	0.2222
p.S3240Y	DO43025	UCEC	ICGC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation rewiring degron network	0.25
p.S3240Y	DO43025	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	3235:3239	Mutation rewiring degron network	0.3056
p.S2747Y	DO41644	UCEC	ICGC	GKENG	DEG_APCC_KENBOX_2	2745:2749	Mutation altering degron motif	0.712
p.R3781C	DO41584	UCEC	ICGC	PPEY	ITCH	3788:3791	Mutation rewiring degron network	0.1389
p.R2809I	DO41572	UCEC	ICGC	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.3056
p.V2208G	DO43971	UCEC	ICGC	QRSKLRIMS	DEG_APCC_DBOX_1	2203:2211	Mutation altering degron motif	0.7532
p.P816A	SIDM00845	Burkitt's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	826:830	Mutation rewiring degron network	0.0556
p.V917A	SIDM00845	Burkitt's Lymphoma	GDSC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.V917A	ACH-000992	Head and Neck Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.V917A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.A922G	SIDM00845	Burkitt's Lymphoma	GDSC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.6429
p.A922G	ACH-000992	Head and Neck Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.6429
p.A922G	Daudi	haematopoietic and lymphoid tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.6429
p.L989P	SIDM00845	Burkitt's Lymphoma	GDSC	LSTPSSS	DEG_SCF_FBW7_1	991:997	Mutation rewiring degron network	0.2778
p.L989P	SIDM00845	Burkitt's Lymphoma	GDSC	PSSST	DEG_SPOP_SBC_1	994:998	Mutation rewiring degron network	0.1944
p.T993A	SIDM00845	Burkitt's Lymphoma	GDSC	LSTPSSS	DEG_SCF_FBW7_1	991:997	Mutation altering degron motif	0.825
p.T993A	SIDM01519	Head and Neck Carcinoma	GDSC	LSTPSSS	DEG_SCF_FBW7_1	991:997	Mutation altering degron motif	0.825
p.T993A	ACH-000786	Lymphoma	CCLE	LSTPSSS	DEG_SCF_FBW7_1	991:997	Mutation altering degron motif	0.825
p.T993A	ACH-001067	Brain Cancer	CCLE	LSTPSSS	DEG_SCF_FBW7_1	991:997	Mutation altering degron motif	0.825
p.T993A	Daudi	haematopoietic and lymphoid tissue	COSMIC	LSTPSSS	DEG_SCF_FBW7_1	991:997	Mutation altering degron motif	0.825
p.T3242A	SIDM00845	Burkitt's Lymphoma	GDSC	IAPSDVVSNMTL	DEG_ODPH_VHL_1	3243:3254	Mutation rewiring degron network	0.3056
p.T3242A	SIDM00845	Burkitt's Lymphoma	GDSC	APSST	DEG_SPOP_SBC_1	3235:3239	Mutation rewiring degron network	0.25
p.K934N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation substituting flanking lysine	0.2778
p.K934N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation substituting flanking lysine	0.1944
p.K934N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation substituting flanking lysine	0.2778
p.K934N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation substituting flanking lysine	0.1944
p.V917I	SIDM00193	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.V917I	ACH-000991	Colon/Colorectal Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.V917I	SNU-81	large intestine	COSMIC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.S947Y	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation rewiring degron network	0.3056
p.V74F	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.0833
p.L2877F	SIDM00373	Endometrial Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	2867:2871	Mutation rewiring degron network	0.1667
p.L2877F	SNG-M	endometrium	COSMIC	PESSS	DEG_SPOP_SBC_1	2867:2871	Mutation rewiring degron network	0.1667
p.G76A	SIDM00988	Kidney Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.1389
p.G73E	SIDM00469	Pancreatic Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.0556
p.G73E	SIDM00173	Head and Neck Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.0556
p.S763G	SIDM00217	Colorectal Carcinoma	GDSC	PLTPPSS	DEG_SCF_FBW7_1	769:775	Mutation rewiring degron network	0.1667
p.S763G	ACH-000999	Colon/Colorectal Cancer	CCLE	PLTPPSS	DEG_SCF_FBW7_1	769:775	Mutation rewiring degron network	0.1667
p.S763G	SNU-1040	large intestine	COSMIC	PLTPPSS	DEG_SCF_FBW7_1	769:775	Mutation rewiring degron network	0.1667
p.R2207W	SIDM00217	Colorectal Carcinoma	GDSC	QRSKLRIMS	DEG_APCC_DBOX_1	2203:2211	Mutation altering degron motif	0.8634
p.R2207W	ACH-000999	Colon/Colorectal Cancer	CCLE	QRSKLRIMS	DEG_APCC_DBOX_1	2203:2211	Mutation altering degron motif	0.8634
p.R2207W	SNU-1040	large intestine	COSMIC	QRSKLRIMS	DEG_APCC_DBOX_1	2203:2211	Mutation altering degron motif	0.8634
p.R721Q	SIDM00534	Colorectal Carcinoma	GDSC	AGTSS	DEG_SPOP_SBC_1	724:728	Mutation rewiring degron network	0.25
p.R721Q	ACH-000986	Colon/Colorectal Cancer	CCLE	AGTSS	DEG_SPOP_SBC_1	724:728	Mutation rewiring degron network	0.25
p.R721Q	HT-115	large intestine	COSMIC	AGTSS	DEG_SPOP_SBC_1	724:728	Mutation rewiring degron network	0.25
p.E766Q	SIDM01498	Acute Myeloid Leukemia	GDSC	PLTPPSS	DEG_SCF_FBW7_1	769:775	Mutation rewiring degron network	0.25
p.E766Q	ACH-000487	Leukemia	CCLE	PLTPPSS	DEG_SCF_FBW7_1	769:775	Mutation rewiring degron network	0.25
p.D920G	SIDM01394	Kidney Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.3056
p.D920G	ACH-000907	Kidney Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.3056
p.S2819P	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.1944
p.S2819P	ACH-000553	Lung Cancer	CCLE	VHTST	DEG_SPOP_SBC_1	2810:2814	Mutation rewiring degron network	0.1944
p.S764R	SIDM01588	Endometrial Carcinoma	GDSC	PLTPPSS	DEG_SCF_FBW7_1	769:775	Mutation rewiring degron network	0.1944
p.S764R	ACH-000993	Endometrial/Uterine Cancer	CCLE	PLTPPSS	DEG_SCF_FBW7_1	769:775	Mutation rewiring degron network	0.1944
p.S759N	ACH-000554	Breast Cancer	CCLE	PLTPPSS	DEG_SCF_FBW7_1	769:775	Mutation rewiring degron network	0.0556
p.S941F	ACH-000836	Head and Neck Cancer	CCLE	DSGTDIT	DEG_SCF_TRCP1_1	940:946	Mutation altering degron motif	0.7982
p.L2874F	ACH-000974	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	2867:2871	Mutation rewiring degron network	0.25
p.L2874F	SNG-M	endometrium	COSMIC	PESSS	DEG_SPOP_SBC_1	2867:2871	Mutation rewiring degron network	0.25
p.T3239A	ACH-000992	Head and Neck Cancer	CCLE	APSST	DEG_SPOP_SBC_1	3235:3239	Mutation altering degron motif	0.7139
p.Q3321R	ACH-000993	Endometrial/Uterine Cancer	CCLE	AGTST	DEG_SPOP_SBC_1	3314:3318	Mutation rewiring degron network	0.25
p.M3349V	ACH-001356	Thyroid Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	3335:3339	Mutation rewiring degron network	0.0556
p.R2204W	SNU-1040	large intestine	COSMIC	QRSKLRIMS	DEG_APCC_DBOX_1	2203:2211	Mutation altering degron motif	0.8634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KMT2A

UniProt ID: Q03164

Entrez ID: 4297

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KMT2A in