DegronMD

Uniprot ID: Q03164

Source protein: Histone-lysine N-methyltransferase 2A

Source gene: KMT2A

Class: DEG_SPOP_SBC_1

Location: 3314:3318

E3 ligase: SPOP

DEGRON score: 0.9902

ASA_SCORE: 74.08

COIL: 0.9144

CONS_SCORE: 0.2809

DSS_SCORE: 0.4505

HELIX: 0.0264

FCONS_SCORE: 0.7684

RIG_SCORE: 0.6977

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3323N	TCGA-29-1771	OV	TCGA	AGTST	DEG_SPOP_SBC_1	0.1944
p.T3326I	TCGA-A5-A0G2	UCEC	TCGA	AGTST	DEG_SPOP_SBC_1	0.1111
p.A3318V	DO219724	CESC	ICGC	AGTST	DEG_SPOP_SBC_1	0.6936
p.A3318V	DO10758	COAD	ICGC	AGTST	DEG_SPOP_SBC_1	0.6936
p.A3318V	DO51766	STAD	ICGC	AGTST	DEG_SPOP_SBC_1	0.6936
p.V3306I	DO230953	LUSC	ICGC	AGTST	DEG_SPOP_SBC_1	0.1111
p.V3306I	DO224624	LUSC	ICGC	AGTST	DEG_SPOP_SBC_1	0.1111
p.V3306I	DO43899	UCEC	ICGC	AGTST	DEG_SPOP_SBC_1	0.1111
p.Q3321R	ACH-000993	Endometrial/Uterine Cancer	CCLE	AGTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2IDD5	Coiled-coil domain-containing protein 78	DEG_SPOP_SBC_1	432:436	AGTST	SPOP	0.8882	More...
O75165	DnaJ homolog subfamily C member 13	DEG_SPOP_SBC_1	2218:2222	AGTST	SPOP	0.9952	More...
O96008	Mitochondrial import receptor subunit TOM40 homolog	DEG_SPOP_SBC_1	46:50	AGTST	SPOP	0.8387	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	3314:3318	AGTST	SPOP	0.9902	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	543:547	AGTST	SPOP	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons