DegronMD

Uniprot ID: A2IDD5

Source protein: Coiled-coil domain-containing protein 78

Source gene: CCDC78

Class: DEG_SPOP_SBC_1

Location: 432:436

E3 ligase: SPOP

DEGRON score: 0.8882

ASA_SCORE: 72.52

COIL: 0.797

CONS_SCORE: 0.6864

DSS_SCORE: 0.6702

HELIX: 0.0298

FCONS_SCORE: 1.0684

RIG_SCORE: 0.7333

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T426M	TCGA-AA-3947	COAD	TCGA	AGTST	DEG_SPOP_SBC_1	0.1667
p.T426M	DO8192	COAD	ICGC	AGTST	DEG_SPOP_SBC_1	0.1667
p.T436M	TCGA-AX-A1CE	UCEC	TCGA	AGTST	DEG_SPOP_SBC_1	0.7423
p.T436M	DO42280	UCEC	ICGC	AGTST	DEG_SPOP_SBC_1	0.7423
p.S435N	DO234350	ESAD	ICGC	AGTST	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2IDD5	Coiled-coil domain-containing protein 78	DEG_SPOP_SBC_1	432:436	AGTST	SPOP	0.8882	More...
O75165	DnaJ homolog subfamily C member 13	DEG_SPOP_SBC_1	2218:2222	AGTST	SPOP	0.9952	More...
O96008	Mitochondrial import receptor subunit TOM40 homolog	DEG_SPOP_SBC_1	46:50	AGTST	SPOP	0.8387	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	3314:3318	AGTST	SPOP	0.9902	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	543:547	AGTST	SPOP	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons