DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
AGTST
Uniprot ID:
O96008
Source protein:
Mitochondrial import receptor subunit TOM40 homolog
Source gene:
TOMM40
Class:
DEG_SPOP_SBC_1
Location:
46:50
E3 ligase:
SPOP
DEGRON score:
0.8387
ASA_SCORE:
64.4
COIL:
0.8698
CONS_SCORE:
0.2378
DSS_SCORE:
0.7256
HELIX:
0.0616
FCONS_SCORE:
0.9072
RIG_SCORE:
0.5794
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R52Q
TCGA-FS-A1ZD
SKCM
TCGA
AGTST
DEG_SPOP_SBC_1
0.2778
p.R52Q
DO37627
SKCM
ICGC
AGTST
DEG_SPOP_SBC_1
0.2778
Drug responses associated with TOMM40 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AGTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A2IDD5
Coiled-coil domain-containing protein 78
DEG_SPOP_SBC_1
432:436
AGTST
SPOP
0.8882
More...
O75165
DnaJ homolog subfamily C member 13
DEG_SPOP_SBC_1
2218:2222
AGTST
SPOP
0.9952
More...
O96008
Mitochondrial import receptor subunit TOM40 homolog
DEG_SPOP_SBC_1
46:50
AGTST
SPOP
0.8387
More...
Q03164
Histone-lysine N-methyltransferase 2A
DEG_SPOP_SBC_1
3314:3318
AGTST
SPOP
0.9902
More...
A6NKL6
Transmembrane protein 200C
DEG_SPOP_SBC_1
543:547
AGTST
SPOP
0.9889
More...