DegronMD

Uniprot ID: O75165

Source protein: DnaJ homolog subfamily C member 13

Source gene: DNAJC13

Class: DEG_SPOP_SBC_1

Location: 2218:2222

E3 ligase: SPOP

DEGRON score: 0.9952

ASA_SCORE: 56.2

COIL: 0.8718

CONS_SCORE: 0.3326

DSS_SCORE: 0.3886

HELIX: 0.058

FCONS_SCORE: 0.7966

RIG_SCORE: 0.715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2217I	TCGA-60-2698	LUSC	TCGA	AGTST	DEG_SPOP_SBC_1	0.3056
p.T2217I	DO26469	LUSC	ICGC	AGTST	DEG_SPOP_SBC_1	0.3056
p.G2214D	TCGA-BR-6452	STAD	TCGA	AGTST	DEG_SPOP_SBC_1	0.2222
p.G2214D	DO38404	STAD	ICGC	AGTST	DEG_SPOP_SBC_1	0.2222
p.G2211V	TCGA-ER-A19P	SKCM	TCGA	AGTST	DEG_SPOP_SBC_1	0.1389
p.G2211V	DO47623	SKCM	ICGC	AGTST	DEG_SPOP_SBC_1	0.1389
p.M2225I	DO52365	LUSC	ICGC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM01169	Ovarian Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM01237	Hepatocellular Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM00602	Gastric Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM01002	Breast Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM00007	Other Solid Cancers	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM01716	Non-Cancerous	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM00175	Melanoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM00214	Colorectal Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM00280	Gastric Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM01721	Non-Cancerous	GDSC	AGTST	DEG_SPOP_SBC_1	0.25
p.M2225I	SIDM01619	Endometrial Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2IDD5	Coiled-coil domain-containing protein 78	DEG_SPOP_SBC_1	432:436	AGTST	SPOP	0.8882	More...
O75165	DnaJ homolog subfamily C member 13	DEG_SPOP_SBC_1	2218:2222	AGTST	SPOP	0.9952	More...
O96008	Mitochondrial import receptor subunit TOM40 homolog	DEG_SPOP_SBC_1	46:50	AGTST	SPOP	0.8387	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	3314:3318	AGTST	SPOP	0.9902	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	543:547	AGTST	SPOP	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons