DegronMD - A6NKL6(TMEM200C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V149M	TCGA-A6-6781	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.V149M	DO8447	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.A140T	TCGA-AA-3713	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2778
p.A140T	DO8400	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2778
p.S146P	TCGA-AP-A1DK	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6752
p.S146P	DO42033	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6752
p.R138Q	TCGA-AX-A2HC	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2222
p.R138Q	TCGA-EE-A20C	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2222
p.R138Q	TCGA-FW-A3R5	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2222
p.R138Q	DO222775	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2222
p.R138Q	DO37406	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2222
p.R138Q	DO47665	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2222
p.R138Q	DO41572	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2222
p.R154H	TCGA-CA-6717	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.R154H	TCGA-CD-8536	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.R154H	TCGA-EO-A22U	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.R154H	TCGA-FI-A2D0	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.R154H	TCGA-NC-A5HN	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.R154H	DO8264	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.R154H	DO52025	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.R154H	DO47827	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.R154H	DO43891	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.R154H	DO43755	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.P117T	TCGA-CR-7364	HNSC	TCGA	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1667
p.P117T	DO15679	HNSC	ICGC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1667
p.L475H	TCGA-DD-AAC8	LIHC	TCGA	DYR	CBL_MET	477:479	Mutation rewiring degron network	0.2778
p.L475H	DO52193	LIHC	ICGC	DYR	CBL_MET	477:479	Mutation rewiring degron network	0.2778
p.S144P	TCGA-E9-A1RB	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6752
p.S144P	DO3757	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6752
p.P530T	TCGA-HF-A5NB	STAD	TCGA	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.25
p.P530T	DO50127	STAD	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.25
p.A128T	TCGA-NH-A5IV	COAD	TCGA	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128T	DO49095	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.Q557E	TCGA-UB-A7MF	LIHC	TCGA	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0556
p.Q557E	DO52322	LIHC	ICGC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0556
p.G150R	TCGA-UF-A71D	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2222
p.G150R	DO52109	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2222
p.P136S	TCGA-WE-AAA0	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.0833
p.P136S	TCGA-WE-AAA0	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.P136S	DO51294	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.0833
p.P136S	DO51294	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.P136S	SIDM00140	Melanoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.0833
p.P136S	SIDM00140	Melanoma	GDSC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.P136S	ACH-000968	Skin Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.0833
p.P136S	ACH-000968	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.P136S	COLO-792	skin	COSMIC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.0833
p.P136S	COLO-792	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.S145Y	TCGA-XF-A9SP	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.712
p.S145Y	DO223598	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.712
p.A553S	TCGA-Z6-A8JE	ESCA	TCGA	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1667
p.A553S	ACH-001370	Ovarian Cancer	CCLE	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1667
p.E548K	TCGA-ZX-AA5X	CESC	TCGA	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.3056
p.E548K	DO219762	CESC	ICGC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.3056
p.S533R	DO222419	BTCA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.1667
p.S533R	DO222419	BTCA	ICGC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.0556
p.A128G	DO230334	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	DO229346	LAML	ICGC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM00330	Neuroblastoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM00377	Other Sarcomas	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM01242	Melanoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM00060	Ovarian Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM00487	Colorectal Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM00241	Breast Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM00302	Other Solid Cancers	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM01779	Gastric Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM01433	Kidney Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.P487L	DO234179	ESAD	ICGC	DYR	CBL_MET	477:479	Mutation rewiring degron network	0.1111
p.R541W	DO233882	GACA	ICGC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2778
p.R541W	SIDM02039	Colorectal Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2778
p.T147M	DO233854	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.3056
p.T147M	DO52672	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.3056
p.P136L	DO228226	LICA	ICGC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.0833
p.P136L	DO228226	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.A555D	DO229015	LICA	ICGC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.1111
p.D529E	DO229034	LICA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.2778
p.D521E	DO229035	LICA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation altering degron motif	0.6758
p.G121W	DO228550	MALY	ICGC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.2778
p.S522F	DO220906	MELA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation altering degron motif	0.7982
p.R541Q	DO222632	MELA	ICGC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2778
p.R541Q	SIDM01203	Other Solid Cancers	GDSC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2778
p.R541Q	ACH-002291	Embryonal Cancer	CCLE	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2778
p.R541Q	NTERA-2_cl_D1	testis	COSMIC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2778
p.P539L	DO222837	MELA	ICGC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.2222
p.P142L	DO50684	ORCA	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7582
p.P488S	DO47331	SKCM	ICGC	DYR	CBL_MET	477:479	Mutation rewiring degron network	0.0833
p.L467S	DO229221	THCA	ICGC	DYR	CBL_MET	477:479	Mutation rewiring degron network	0.0556
p.R154S	SIDM02059	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1111
p.S126C	SIDM01314	Colorectal Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.7541
p.F151C	SIDM01179	Other Sarcomas	GDSC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944
p.D528E	SIDM00594	Acute Myeloid Leukemia	GDSC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.3056
p.D528E	ACH-000004	Leukemia	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.3056
p.D528E	ACH-000005	Leukemia	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.3056
p.D528E	HEL	haematopoietic and lymphoid tissue	COSMIC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.3056
p.S115R	SIDM00846	Cervical Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1111
p.S115R	ACH-001086	Cervical Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1111
p.S115R	HeLa	cervix	COSMIC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1111
p.V149G	SIDM01129	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.V149G	ACH-000816	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.V149G	NCI-H524	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.G122C	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.G122C	ACH-000809	Esophageal Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.G122C	KYSE-410	oesophagus	COSMIC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128V	SIDM00660	Colorectal Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128V	LS-411N	large intestine	COSMIC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.P530L	SIDM00260	Gastric Carcinoma	GDSC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.25
p.P530L	SIDM00248	Gastric Carcinoma	GDSC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.25
p.P530L	ACH-000758	Gastric Cancer	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.25
p.P530L	MKN28	stomach	COSMIC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.25
p.S515W	SIDM00346	Chronic Myelogenous Leukemia	GDSC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.1667
p.S515W	ACH-000301	Leukemia	CCLE	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation rewiring degron network	0.1667
p.R118M	SIDM01609	Endometrial Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1944
p.R118M	ACH-000972	Endometrial/Uterine Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1944
p.S546C	SIDM01665	Colorectal Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7541
p.S546C	ACH-000089	Colon/Colorectal Cancer	CCLE	AGTST	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7541

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM200C

UniProt ID: A6NKL6

Entrez ID: 645369

Protein name: Transmembrane protein 200C (Transmembrane protein TTMA) (Two transmembrane domain-containing family member A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM200C in