DegronMD - A6NKL6(TMEM200C)

GO - Biological processes (BP):

GO - Molecular function (MF):

GO - Cellular component (CC): integral component of membrane [GO:0016021]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S522F	DO220906	MELA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation altering degron motif	0.7982
p.P142L	DO50684	ORCA	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7582
p.S126C	SIDM01314	Colorectal Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.7541
p.S546C	SIDM01665	Colorectal Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7541
p.S546C	ACH-000089	Colon/Colorectal Cancer	CCLE	AGTST	DEG_SPOP_SBC_1	543:547	Mutation altering degron motif	0.7541
p.S145Y	TCGA-XF-A9SP	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.712
p.S145Y	DO223598	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.712
p.D521E	DO229035	LICA	ICGC	DSGSSQS	DEG_SCF_TRCP1_1	521:527	Mutation altering degron motif	0.6758
p.S146P	TCGA-AP-A1DK	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6752
p.S146P	DO42033	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6752
p.S144P	TCGA-E9-A1RB	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6752
p.S144P	DO3757	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.6752
p.A128T	TCGA-NH-A5IV	COAD	TCGA	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128T	DO49095	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.E548K	TCGA-ZX-AA5X	CESC	TCGA	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.3056
p.E548K	DO219762	CESC	ICGC	AGTST	DEG_SPOP_SBC_1	543:547	Mutation rewiring degron network	0.3056
p.A128G	DO230334	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	DO229346	LAML	ICGC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM00330	Neuroblastoma	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056
p.A128G	SIDM00377	Other Sarcomas	GDSC	VNSSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 117 entries

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Kaplan plot for TMEM200C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM200C

UniProt ID: A6NKL6

Entrez ID: 645369

Protein name: Transmembrane protein 200C (Transmembrane protein TTMA) (Two transmembrane domain-containing family member A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM200C in