DegronMD

Uniprot ID: A6NKL6

Source protein: Transmembrane protein 200C

Source gene: TMEM200C

Class: DEG_SPOP_SBC_1

Location: 123:127

E3 ligase: SPOP

DEGRON score: 0.7274

ASA_SCORE: 66.58

COIL: 0.7924

CONS_SCORE: 0.274

DSS_SCORE: 0.756

HELIX: 0.101

FCONS_SCORE: 1.0094

RIG_SCORE: 0.5022

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P117T	TCGA-CR-7364	HNSC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1667
p.P117T	DO15679	HNSC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.A128T	TCGA-NH-A5IV	COAD	TCGA	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128T	DO49095	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.P136S	TCGA-WE-AAA0	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.0833
p.P136S	DO51294	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.0833
p.P136S	SIDM00140	Melanoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.0833
p.P136S	ACH-000968	Skin Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.0833
p.P136S	COLO-792	skin	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.0833
p.A128G	DO230334	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	DO229346	LAML	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM00330	Neuroblastoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM00377	Other Sarcomas	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM01242	Melanoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM00060	Ovarian Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM00487	Colorectal Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM00241	Breast Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM00302	Other Solid Cancers	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM01779	Gastric Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM01433	Kidney Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128G	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.P136L	DO228226	LICA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.0833
p.G121W	DO228550	MALY	ICGC	VNSSS	DEG_SPOP_SBC_1	0.2778
p.S126C	SIDM01314	Colorectal Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.7541
p.S115R	SIDM00846	Cervical Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.S115R	ACH-001086	Cervical Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1111
p.S115R	HeLa	cervix	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.G122C	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.G122C	ACH-000809	Esophageal Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.3056
p.G122C	KYSE-410	oesophagus	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128V	SIDM00660	Colorectal Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A128V	LS-411N	large_intestine	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.R118M	SIDM01609	Endometrial Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1944
p.R118M	ACH-000972	Endometrial/Uterine Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14924	Regulator of G-protein signaling 12	DEG_SPOP_SBC_1	1127:1131	VNSSS	SPOP	0.8442	More...
P06241	Tyrosine-protein kinase Fyn	DEG_SPOP_SBC_1	67:71	VNSSS	SPOP	0.9672	More...
P21453	Sphingosine 1-phosphate receptor 1	DEG_SPOP_SBC_1	378:382	VNSSS	SPOP	0.977	More...
Q12889	Oviduct-specific glycoprotein	DEG_SPOP_SBC_1	401:405	VNSSS	SPOP	0.965	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	197:201	VNSSS	SPOP	0.9915	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	342:346	VNSSS	SPOP	0.968	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_SPOP_SBC_1	454:458	VNSSS	SPOP	0.8991	More...
Q7L4E1	Mitoguardin 2	DEG_SPOP_SBC_1	144:148	VNSSS	SPOP	0.9606	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5227:5231	VNSSS	SPOP	0.8577	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	574:578	VNSSS	SPOP	0.9912	More...
Q99598	Translin-associated protein X	DEG_SPOP_SBC_1	29:33	VNSSS	SPOP	0.9939	More...
A6NGB9	WAS/WASL-interacting protein family member 3	DEG_SPOP_SBC_1	316:320	VNSSS	SPOP	0.946	More...
P51522	Zinc finger protein 83	DEG_SPOP_SBC_1	47:51	VNSSS	SPOP	0.6424	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1624:1628	VNSSS	SPOP	0.9986	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	123:127	VNSSS	SPOP	0.7274	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VNSSS

Degron related mutations and impact score

Drug responses associated with TMEM200C mutations

All proteins holding degron of VNSSS