DegronMD - A6NGB9(WIPF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P309H	TCGA-AA-3864	COAD	TCGA	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1389
p.P309H	DO8490	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1389
p.A310V	TCGA-F4-6703	COAD	TCGA	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1667
p.A310V	DO9908	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1667
p.A310V	DO50314	ESAD	ICGC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1667
p.A310V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1667
p.A310V	ACH-002256	Leukemia	CCLE	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1667
p.A310V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1667
p.P309L	TCGA-FW-A3R5	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1389
p.P309L	DO37406	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1389
p.E321G	DO230334	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.3056
p.E321G	DO229005	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.3056
p.A310T	DO233941	GACA	ICGC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1667
p.P323L	DO222363	MELA	ICGC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.25
p.S330F	DO222599	MELA	ICGC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0556
p.P328L	DO222662	MELA	ICGC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1111
p.G205R	DO229272	THCA	ICGC	PIKTPLVS	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.25
p.P328A	SIDM00131	Glioma	GDSC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1111
p.P328A	SIDM00965	Small Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1111
p.P328A	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1111
p.P312H	SIDM00220	Ovarian Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.2222
p.P312H	ACH-000962	Ovarian Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.2222
p.P312H	ACH-001145	Ovarian Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.2222
p.P312H	OC-314	ovary	COSMIC	VNSSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.2222
p.K197I	ACH-000155	Pancreatic Cancer	CCLE	PIKTPLVS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.642

Kaplan plot for WIPF3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WIPF3

UniProt ID: A6NGB9

Entrez ID: 644150

Protein name: WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WIPF3 in