DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PIKTPLVS
Uniprot ID:
A6NGB9
Source protein:
WAS/WASL-interacting protein family member 3
Source gene:
WIPF3
Class:
DEG_SCF_FBW7_1
Location:
195:202
E3 ligase:
FBXW7
DEGRON score:
0.9959
ASA_SCORE:
100.6375
COIL:
0.9649
CONS_SCORE:
0.3857
DSS_SCORE:
0.6444
HELIX:
0.0133
FCONS_SCORE:
0.8893
RIG_SCORE:
0.5784
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G205R
DO229272
THCA
ICGC
PIKTPLVS
DEG_SCF_FBW7_1
0.25
p.K197I
ACH-000155
Pancreatic Cancer
CCLE
PIKTPLVS
DEG_SCF_FBW7_1
0.642
Drug responses associated with WIPF3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PIKTPLVS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NGB9
WAS/WASL-interacting protein family member 3
DEG_SCF_FBW7_1
195:202
PIKTPLVS
FBXW7
0.9959
More...