DegronMD

Uniprot ID: A6NGB9

Source protein: WAS/WASL-interacting protein family member 3

Source gene: WIPF3

Class: DEG_SPOP_SBC_1

Location: 316:320

E3 ligase: SPOP

DEGRON score: 0.946

ASA_SCORE: 79.66

COIL: 0.9306

CONS_SCORE: 0.287

DSS_SCORE: 0.7094

HELIX: 0.0466

FCONS_SCORE: 0.6243

RIG_SCORE: 0.4901

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P309H	TCGA-AA-3864	COAD	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1389
p.P309H	DO8490	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.A310V	TCGA-F4-6703	COAD	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1667
p.A310V	DO9908	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.A310V	DO50314	ESAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.A310V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.A310V	ACH-002256	Leukemia	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1667
p.A310V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.P309L	TCGA-FW-A3R5	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1389
p.P309L	DO37406	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.E321G	DO230334	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.E321G	DO229005	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A310T	DO233941	GACA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.P323L	DO222363	MELA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.S330F	DO222599	MELA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.0556
p.P328L	DO222662	MELA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.P328A	SIDM00131	Glioma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.P328A	SIDM00965	Small Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.P328A	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.P312H	SIDM00220	Ovarian Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.2222
p.P312H	ACH-000962	Ovarian Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.2222
p.P312H	ACH-001145	Ovarian Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.2222
p.P312H	OC-314	ovary	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14924	Regulator of G-protein signaling 12	DEG_SPOP_SBC_1	1127:1131	VNSSS	SPOP	0.8442	More...
P06241	Tyrosine-protein kinase Fyn	DEG_SPOP_SBC_1	67:71	VNSSS	SPOP	0.9672	More...
P21453	Sphingosine 1-phosphate receptor 1	DEG_SPOP_SBC_1	378:382	VNSSS	SPOP	0.977	More...
Q12889	Oviduct-specific glycoprotein	DEG_SPOP_SBC_1	401:405	VNSSS	SPOP	0.965	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	197:201	VNSSS	SPOP	0.9915	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	342:346	VNSSS	SPOP	0.968	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_SPOP_SBC_1	454:458	VNSSS	SPOP	0.8991	More...
Q7L4E1	Mitoguardin 2	DEG_SPOP_SBC_1	144:148	VNSSS	SPOP	0.9606	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5227:5231	VNSSS	SPOP	0.8577	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	574:578	VNSSS	SPOP	0.9912	More...
Q99598	Translin-associated protein X	DEG_SPOP_SBC_1	29:33	VNSSS	SPOP	0.9939	More...
A6NGB9	WAS/WASL-interacting protein family member 3	DEG_SPOP_SBC_1	316:320	VNSSS	SPOP	0.946	More...
P51522	Zinc finger protein 83	DEG_SPOP_SBC_1	47:51	VNSSS	SPOP	0.6424	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1624:1628	VNSSS	SPOP	0.9986	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	123:127	VNSSS	SPOP	0.7274	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons