DegronMD

Uniprot ID: O14924

Source protein: Regulator of G-protein signaling 12

Source gene: RGS12

Class: DEG_SPOP_SBC_1

Location: 1127:1131

E3 ligase: SPOP

DEGRON score: 0.8442

ASA_SCORE: 74.26

COIL: 0.8382

CONS_SCORE: 0.3572

DSS_SCORE: 0.694

HELIX: 0.1146

FCONS_SCORE: 0.9747

RIG_SCORE: 0.6149

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1126T	TCGA-AX-A1CE	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A1126T	DO42280	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.T1137M	TCGA-CG-5726	STAD	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1667
p.T1137M	DO38483	STAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.N1124S	DO229346	LAML	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.N1124S	DO229047	LICA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.N1124S	DO230541	LUSC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.N1124S	DO52365	LUSC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.E1139D	DO228952	LICA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.V1121L	DO229008	LICA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.V1121L	SIDM00503	Gastric Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.V1121L	SIDM01770	Gastric Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.V1121L	FU97	stomach	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.A1126G	DO228338	MALY	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A1126G	SIDM00948	Burkitt's Lymphoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A1126G	ACH-002232	Lymphoma	CCLE	VNSSS	DEG_SPOP_SBC_1	0.3056
p.A1126G	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.P1120L	SIDM00308	Chronic Myelogenous Leukemia	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14924	Regulator of G-protein signaling 12	DEG_SPOP_SBC_1	1127:1131	VNSSS	SPOP	0.8442	More...
P06241	Tyrosine-protein kinase Fyn	DEG_SPOP_SBC_1	67:71	VNSSS	SPOP	0.9672	More...
P21453	Sphingosine 1-phosphate receptor 1	DEG_SPOP_SBC_1	378:382	VNSSS	SPOP	0.977	More...
Q12889	Oviduct-specific glycoprotein	DEG_SPOP_SBC_1	401:405	VNSSS	SPOP	0.965	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	197:201	VNSSS	SPOP	0.9915	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	342:346	VNSSS	SPOP	0.968	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_SPOP_SBC_1	454:458	VNSSS	SPOP	0.8991	More...
Q7L4E1	Mitoguardin 2	DEG_SPOP_SBC_1	144:148	VNSSS	SPOP	0.9606	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5227:5231	VNSSS	SPOP	0.8577	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	574:578	VNSSS	SPOP	0.9912	More...
Q99598	Translin-associated protein X	DEG_SPOP_SBC_1	29:33	VNSSS	SPOP	0.9939	More...
A6NGB9	WAS/WASL-interacting protein family member 3	DEG_SPOP_SBC_1	316:320	VNSSS	SPOP	0.946	More...
P51522	Zinc finger protein 83	DEG_SPOP_SBC_1	47:51	VNSSS	SPOP	0.6424	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1624:1628	VNSSS	SPOP	0.9986	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	123:127	VNSSS	SPOP	0.7274	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons