DegronMD

Uniprot ID: P06241

Source protein: Tyrosine-protein kinase Fyn

Source gene: FYN

Class: DEG_SPOP_SBC_1

Location: 67:71

E3 ligase: SPOP

DEGRON score: 0.9672

ASA_SCORE: 78.38

COIL: 0.9294

CONS_SCORE: 0.3953

DSS_SCORE: 0.3516

HELIX: 0.0472

FCONS_SCORE: 0.9852

RIG_SCORE: 0.6765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G81R	TCGA-B5-A1MX	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.0556
p.G81R	DO41999	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.0556
p.T73M	TCGA-DK-A6AW	BLCA	TCGA	VNSSS	DEG_SPOP_SBC_1	0.2778
p.T73M	TCGA-EO-A22X	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.2778
p.T73M	TCGA-EO-A3AZ	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.2778
p.T73M	DO48566	BLCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.2778
p.T73M	DO50078	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.2778
p.T73M	DO43907	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.2778
p.S70L	TCGA-DK-A6AW	BLCA	TCGA	VNSSS	DEG_SPOP_SBC_1	0.7667
p.S70L	TCGA-E6-A1LX	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.7667
p.S70L	TCGA-EO-A3B0	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.7667
p.S70L	DO48566	BLCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.7667
p.S70L	DO219773	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.7667
p.S70L	DO41020	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.7667
p.S70L	SIDM01179	Other Sarcomas	GDSC	VNSSS	DEG_SPOP_SBC_1	0.7667
p.S70L	ACH-001702	Sarcoma	CCLE	VNSSS	DEG_SPOP_SBC_1	0.7667
p.S70L	VA-ES-BJ	bone	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.7667
p.S69Y	TCGA-EO-A3B0	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.712
p.S69Y	DO219773	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.712
p.R77C	TCGA-QG-A5Z2	COAD	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1667
p.R77C	DO44096	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.V63I	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.2222
p.V63I	JVM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.2222
p.R77H	ACH-001061	Colon/Colorectal Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1667

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00461	LAML\|acute_myeloid_leukaemia	p.A246S (No)	GDSC	A-770041	10.3234
SIDM00461	LAML\|acute_myeloid_leukaemia	p.I245V (No)	GDSC	A-770041	10.3234
SIDM00085	GBM\|glioma	p.D19G (No)	GDSC	A-770041	3.125
SIDM00516	SKCM\|melanoma	p.G410R (No)	GDSC	A-770041	13.9703
SIDM01197	COREAD\|large_intestine	p.D99V (No)	GDSC	A-770041	153.3747
SIDM01117	SCLC\|lung_small_cell_carcinoma	p.G183V (No)	GDSC	A-770041	37.5293
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R266G (No)	GDSC	A-770041	0.9828
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A246S (No)	GDSC	A-770041	0.9828
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I245V (No)	GDSC	A-770041	0.9828
SIDM01013	CLL\|lymphoid_neoplasm_other	p.V63I (Yes)	GDSC	A-770041	25.0351
SIDM01179	UNCLASSIFIED\|soft_tissue_other	p.S70L (Yes)	GDSC	A-770041	10.1506

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14924	Regulator of G-protein signaling 12	DEG_SPOP_SBC_1	1127:1131	VNSSS	SPOP	0.8442	More...
P06241	Tyrosine-protein kinase Fyn	DEG_SPOP_SBC_1	67:71	VNSSS	SPOP	0.9672	More...
P21453	Sphingosine 1-phosphate receptor 1	DEG_SPOP_SBC_1	378:382	VNSSS	SPOP	0.977	More...
Q12889	Oviduct-specific glycoprotein	DEG_SPOP_SBC_1	401:405	VNSSS	SPOP	0.965	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	197:201	VNSSS	SPOP	0.9915	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	342:346	VNSSS	SPOP	0.968	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_SPOP_SBC_1	454:458	VNSSS	SPOP	0.8991	More...
Q7L4E1	Mitoguardin 2	DEG_SPOP_SBC_1	144:148	VNSSS	SPOP	0.9606	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5227:5231	VNSSS	SPOP	0.8577	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	574:578	VNSSS	SPOP	0.9912	More...
Q99598	Translin-associated protein X	DEG_SPOP_SBC_1	29:33	VNSSS	SPOP	0.9939	More...
A6NGB9	WAS/WASL-interacting protein family member 3	DEG_SPOP_SBC_1	316:320	VNSSS	SPOP	0.946	More...
P51522	Zinc finger protein 83	DEG_SPOP_SBC_1	47:51	VNSSS	SPOP	0.6424	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1624:1628	VNSSS	SPOP	0.9986	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	123:127	VNSSS	SPOP	0.7274	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons