DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 5227:5231

E3 ligase: SPOP

DEGRON score: 0.8577

ASA_SCORE: 85.36

COIL: 0.8612

CONS_SCORE: 0

DSS_SCORE: 0.5533

HELIX: 0.0174

FCONS_SCORE: 0

RIG_SCORE: 0.6258

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K5240E	TCGA-06-0216	GBM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1944
p.K5240E	DO11388	GBM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1944
p.T5225A	TCGA-AX-A0J0	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.2778
p.T5225A	DO41133	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.2778
p.K5240T	TCGA-BR-6454	STAD	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1944
p.K5240T	DO38595	STAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1944
p.K5232T	TCGA-BR-6563	STAD	TCGA	VNSSS	DEG_SPOP_SBC_1	0.3056
p.K5232T	DO234413	ESAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.K5232T	DO38364	STAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.S5224T	TCGA-BT-A3PH	BLCA	TCGA	VNSSS	DEG_SPOP_SBC_1	0.25
p.S5224T	DO856	BLCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.S5234F	TCGA-D9-A6EC	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.25
p.S5234F	TCGA-EE-A29D	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.25
p.S5234F	TCGA-W3-AA1Q	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.25
p.S5234F	TCGA-YD-A89C	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.25
p.S5234F	DO220895	MELA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.S5234F	DO222567	MELA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.S5234F	DO50291	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.S5234F	DO38123	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.S5234F	DO219487	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.S5234F	DO219501	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.D5239N	TCGA-DK-A1A3	BLCA	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1111
p.D5239N	DO558	BLCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.N5228K	DO8898	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.5806
p.N5228I	DO229010	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.6169
p.N5228I	DO229013	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.6169
p.N5228I	DO229016	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.6169
p.N5228I	DO229003	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.6169
p.N5228I	DO229005	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.6169
p.I5233L	DO50325	ESAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.2778
p.I5233S	DO234449	ESAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.2778
p.P5236T	DO229028	LICA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1944
p.K5232N	DO230950	LUSC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.K5232N	DO224638	LUSC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.K5232N	DO34809	PACA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.G5226E	DO233295	NACA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.I5233M	DO232224	PBCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.2778
p.S5231G	DO233978	THCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.6993
p.I5219T	SIDM01129	Small Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.I5219T	ACH-000816	Lung Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1111
p.I5219T	NCI-H524	lung	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.H5238Y	SIDM01056	Breast Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.H5238Y	ACH-000330	Breast Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1389
p.H5238Y	EFM-19	breast	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14924	Regulator of G-protein signaling 12	DEG_SPOP_SBC_1	1127:1131	VNSSS	SPOP	0.8442	More...
P06241	Tyrosine-protein kinase Fyn	DEG_SPOP_SBC_1	67:71	VNSSS	SPOP	0.9672	More...
P21453	Sphingosine 1-phosphate receptor 1	DEG_SPOP_SBC_1	378:382	VNSSS	SPOP	0.977	More...
Q12889	Oviduct-specific glycoprotein	DEG_SPOP_SBC_1	401:405	VNSSS	SPOP	0.965	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	197:201	VNSSS	SPOP	0.9915	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	342:346	VNSSS	SPOP	0.968	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_SPOP_SBC_1	454:458	VNSSS	SPOP	0.8991	More...
Q7L4E1	Mitoguardin 2	DEG_SPOP_SBC_1	144:148	VNSSS	SPOP	0.9606	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5227:5231	VNSSS	SPOP	0.8577	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	574:578	VNSSS	SPOP	0.9912	More...
Q99598	Translin-associated protein X	DEG_SPOP_SBC_1	29:33	VNSSS	SPOP	0.9939	More...
A6NGB9	WAS/WASL-interacting protein family member 3	DEG_SPOP_SBC_1	316:320	VNSSS	SPOP	0.946	More...
P51522	Zinc finger protein 83	DEG_SPOP_SBC_1	47:51	VNSSS	SPOP	0.6424	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1624:1628	VNSSS	SPOP	0.9986	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	123:127	VNSSS	SPOP	0.7274	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VNSSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VNSSS