DegronMD

Uniprot ID: Q96KQ4

Source protein: Apoptosis-stimulating of p53 protein 1

Source gene: PPP1R13B

Class: DEG_SPOP_SBC_1

Location: 574:578

E3 ligase: SPOP

DEGRON score: 0.9912

ASA_SCORE: 71.36

COIL: 0.7956

CONS_SCORE: 0.4997

DSS_SCORE: 0.5566

HELIX: 0.1168

FCONS_SCORE: 1.0235

RIG_SCORE: 0.6747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S566F	TCGA-98-8021	LUSC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.5556
p.S566F	DO27468	LUSC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.5556
p.N575K	TCGA-AX-A2HD	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.5806
p.N575K	DO42608	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.5806
p.N575S	DO231622	LINC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.5958
p.Q565H	SIDM00652	Small Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.0833
p.Q565H	ACH-000780	Lung Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.0833
p.Q565H	NCI-H1105	lung	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.0833
p.P564S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VNSSS	DEG_SPOP_SBC_1	0.0556
p.P564S	ACH-001669	Leukemia	CCLE	VNSSS	DEG_SPOP_SBC_1	0.0556
p.P564S	ACH-002238	Leukemia	CCLE	VNSSS	DEG_SPOP_SBC_1	0.0556
p.P564S	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.0556
p.P567L	SIDM00853	Other Sarcomas	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.P567L	ACH-000835	Sarcoma	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1389
p.P567L	GCT	soft_tissue	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14924	Regulator of G-protein signaling 12	DEG_SPOP_SBC_1	1127:1131	VNSSS	SPOP	0.8442	More...
P06241	Tyrosine-protein kinase Fyn	DEG_SPOP_SBC_1	67:71	VNSSS	SPOP	0.9672	More...
P21453	Sphingosine 1-phosphate receptor 1	DEG_SPOP_SBC_1	378:382	VNSSS	SPOP	0.977	More...
Q12889	Oviduct-specific glycoprotein	DEG_SPOP_SBC_1	401:405	VNSSS	SPOP	0.965	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	197:201	VNSSS	SPOP	0.9915	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	342:346	VNSSS	SPOP	0.968	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_SPOP_SBC_1	454:458	VNSSS	SPOP	0.8991	More...
Q7L4E1	Mitoguardin 2	DEG_SPOP_SBC_1	144:148	VNSSS	SPOP	0.9606	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5227:5231	VNSSS	SPOP	0.8577	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	574:578	VNSSS	SPOP	0.9912	More...
Q99598	Translin-associated protein X	DEG_SPOP_SBC_1	29:33	VNSSS	SPOP	0.9939	More...
A6NGB9	WAS/WASL-interacting protein family member 3	DEG_SPOP_SBC_1	316:320	VNSSS	SPOP	0.946	More...
P51522	Zinc finger protein 83	DEG_SPOP_SBC_1	47:51	VNSSS	SPOP	0.6424	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1624:1628	VNSSS	SPOP	0.9986	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	123:127	VNSSS	SPOP	0.7274	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons