DegronMD - Q96KQ4(PPP1R13B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E19K	TCGA-93-8067	LUAD	TCGA	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.3056
p.E19K	DO25113	LUAD	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.3056
p.S566F	TCGA-98-8021	LUSC	TCGA	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation blocking phosphorylation signal	0.5556
p.S566F	DO27468	LUSC	ICGC	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation blocking phosphorylation signal	0.5556
p.Q15H	TCGA-A5-A1OF	UCEC	TCGA	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.1944
p.Q15H	DO42568	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.1944
p.L853V	TCGA-AC-A23H	BRCA	TCGA	PATST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1389
p.N575K	TCGA-AX-A2HD	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.5806
p.N575K	DO42608	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.5806
p.P24S	TCGA-BF-AAP1	SKCM	TCGA	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation altering degron motif	0.6752
p.P24S	DO219464	SKCM	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation altering degron motif	0.6752
p.P450H	TCGA-CN-6010	HNSC	TCGA	PPSY	ITCH	459:462	Mutation rewiring degron network	0.0833
p.P450H	DO14766	HNSC	ICGC	PPSY	ITCH	459:462	Mutation rewiring degron network	0.0833
p.L10F	TCGA-D3-A2JB	SKCM	TCGA	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.0556
p.L10F	DO47607	SKCM	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.0556
p.I16S	TCGA-DF-A2KU	UCEC	TCGA	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.2222
p.I16S	DO223286	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.2222
p.E484K	TCGA-EE-A2M5	SKCM	TCGA	PGSTS	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1389
p.E484K	DO222423	MELA	ICGC	PGSTS	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1389
p.E484K	DO37425	SKCM	ICGC	PGSTS	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1389
p.N13S	TCGA-FI-A2D5	UCEC	TCGA	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.1389
p.N13S	DO41331	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.1389
p.N869S	TCGA-FR-A729	SKCM	TCGA	PATST	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1944
p.P21S	TCGA-HR-A2OH	SKCM	TCGA	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation altering degron motif	0.5641
p.P21S	DO37774	SKCM	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation altering degron motif	0.5641
p.P21S	SIDM01059	Melanoma	GDSC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation altering degron motif	0.5641
p.P21S	ACH-000915	Skin Cancer	CCLE	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation altering degron motif	0.5641
p.P21S	IPC-298	skin	COSMIC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation altering degron motif	0.5641
p.A350T	DO49806	BLCA	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0556
p.A350T	DO41199	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0556
p.P333A	DO233144	GACA	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.25
p.P14T	DO229024	LICA	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.1667
p.P24T	DO229027	LICA	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation altering degron motif	0.7031
p.N12K	DO229035	LICA	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.1111
p.A345D	DO229038	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1944
p.T330K	DO229041	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation blocking phosphorylation signal	0.6111
p.H345Q	DO229008	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1944
p.V348I	DO49709	LIHC	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.V348I	DO35083	PACA	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1111
p.N575S	DO231622	LINC	ICGC	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.5958
p.H345Y	DO45299	LIRI	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1944
p.A347S	DO51197	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1389
p.S340L	DO220891	MELA	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation altering degron motif	0.7667
p.S340L	SIDM01174	Cervical Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation altering degron motif	0.7667
p.S340L	ACH-001402	Cervical Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation altering degron motif	0.7667
p.S340L	SW756	cervix	COSMIC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation altering degron motif	0.7667
p.P333T	DO50678	ORCA	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.25
p.P31T	DO229259	THCA	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.2222
p.V32I	DO42033	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.1944
p.K10N	DO43041	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.0556
p.A19T	DO42977	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	20:27	Mutation rewiring degron network	0.3056
p.P333H	DO42408	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.25
p.Y465H	SIDM02050	Colorectal Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1111
p.Y465H	SIDM02050	Colorectal Carcinoma	GDSC	PPSY	ITCH	459:462	Mutation rewiring degron network	0.25
p.A344T	SIDM01095	Rhabdomyosarcoma	GDSC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2222
p.A344T	ACH-000833	Sarcoma	CCLE	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2222
p.A344T	SJRH30	soft tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2222
p.Q565H	SIDM00652	Small Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0833
p.Q565H	ACH-000780	Lung Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0833
p.Q565H	NCI-H1105	lung	COSMIC	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0833
p.P564S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.P564S	ACH-001669	Leukemia	CCLE	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.P564S	ACH-002238	Leukemia	CCLE	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.P564S	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.0556
p.P567L	SIDM00853	Other Sarcomas	GDSC	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1389
p.P567L	ACH-000835	Sarcoma	CCLE	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1389
p.P567L	GCT	soft tissue	COSMIC	VNSSS	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1389
p.P468L	ACH-001143	Lymphoma	CCLE	PGSTS	DEG_SPOP_SBC_1	473:477	Mutation rewiring degron network	0.1944
p.P468L	ACH-001143	Lymphoma	CCLE	PPSY	ITCH	459:462	Mutation rewiring degron network	0.1667
p.R326H	ACH-001786	Colon/Colorectal Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R13B

UniProt ID: Q96KQ4

Entrez ID: 23368

Protein name: Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP1R13B in