DegronMD

Uniprot ID: Q96KQ4

Source protein: Apoptosis-stimulating of p53 protein 1

Source gene: PPP1R13B

Class: DEG_SCF_FBW7_1

Location: 20:27

E3 ligase: FBXW7

DEGRON score: 0.8579

ASA_SCORE: 52.325

COIL: 0.7451

CONS_SCORE: 0.5738

DSS_SCORE: 0.273

HELIX: 0.0193

FCONS_SCORE: 1.2193

RIG_SCORE: 0.8244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E19K	TCGA-93-8067	LUAD	TCGA	VPITPETT	DEG_SCF_FBW7_1	0.3056
p.E19K	DO25113	LUAD	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.3056
p.Q15H	TCGA-A5-A1OF	UCEC	TCGA	VPITPETT	DEG_SCF_FBW7_1	0.1944
p.Q15H	DO42568	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.1944
p.P24S	TCGA-BF-AAP1	SKCM	TCGA	VPITPETT	DEG_SCF_FBW7_1	0.6752
p.P24S	DO219464	SKCM	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.6752
p.L10F	TCGA-D3-A2JB	SKCM	TCGA	VPITPETT	DEG_SCF_FBW7_1	0.0556
p.L10F	DO47607	SKCM	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.0556
p.I16S	TCGA-DF-A2KU	UCEC	TCGA	VPITPETT	DEG_SCF_FBW7_1	0.2222
p.I16S	DO223286	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.2222
p.N13S	TCGA-FI-A2D5	UCEC	TCGA	VPITPETT	DEG_SCF_FBW7_1	0.1389
p.N13S	DO41331	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.1389
p.P21S	TCGA-HR-A2OH	SKCM	TCGA	VPITPETT	DEG_SCF_FBW7_1	0.5641
p.P21S	DO37774	SKCM	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.5641
p.P21S	SIDM01059	Melanoma	GDSC	VPITPETT	DEG_SCF_FBW7_1	0.5641
p.P21S	ACH-000915	Skin Cancer	CCLE	VPITPETT	DEG_SCF_FBW7_1	0.5641
p.P21S	IPC-298	skin	COSMIC	VPITPETT	DEG_SCF_FBW7_1	0.5641
p.P14T	DO229024	LICA	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.1667
p.P24T	DO229027	LICA	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.7031
p.N12K	DO229035	LICA	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.1111
p.P31T	DO229259	THCA	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.2222
p.V32I	DO42033	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.1944
p.K10N	DO43041	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.0556
p.A19T	DO42977	UCEC	ICGC	VPITPETT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SCF_FBW7_1	20:27	VPITPETT	FBXW7	0.8579	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons