DegronMD

Uniprot ID: Q92545

Source protein: Transmembrane protein 131

Source gene: TMEM131

Class: DEG_SPOP_SBC_1

Location: 1624:1628

E3 ligase: SPOP

DEGRON score: 0.9986

ASA_SCORE: 78.94

COIL: 0.9166

CONS_SCORE: 0.3723

DSS_SCORE: 0.5586

HELIX: 0.038

FCONS_SCORE: 1.1851

RIG_SCORE: 0.5984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1617L	TCGA-17-Z049	LUAD	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1389
p.R1617L	TCGA-FS-A1ZR	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1389
p.R1617L	DO37651	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.N1638H	TCGA-A5-A2K5	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.0556
p.N1638H	DO41379	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.0556
p.R1617Q	TCGA-AB-2807	LAML	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1389
p.R1617Q	DO233168	GACA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.R1617Q	DO21589	LAML	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.F1614V	DO230346	COCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.0556
p.S1626R	DO229045	LICA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.7427
p.G1618D	SIDM00072	Non-Cancerous	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1667
p.R1617G	ACH-001190	Skin Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1389
p.I1634T	ACH-001536	Bile Duct Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1667
p.S1628F	ACH-001566	Skin Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14924	Regulator of G-protein signaling 12	DEG_SPOP_SBC_1	1127:1131	VNSSS	SPOP	0.8442	More...
P06241	Tyrosine-protein kinase Fyn	DEG_SPOP_SBC_1	67:71	VNSSS	SPOP	0.9672	More...
P21453	Sphingosine 1-phosphate receptor 1	DEG_SPOP_SBC_1	378:382	VNSSS	SPOP	0.977	More...
Q12889	Oviduct-specific glycoprotein	DEG_SPOP_SBC_1	401:405	VNSSS	SPOP	0.965	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	197:201	VNSSS	SPOP	0.9915	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	342:346	VNSSS	SPOP	0.968	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_SPOP_SBC_1	454:458	VNSSS	SPOP	0.8991	More...
Q7L4E1	Mitoguardin 2	DEG_SPOP_SBC_1	144:148	VNSSS	SPOP	0.9606	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5227:5231	VNSSS	SPOP	0.8577	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	574:578	VNSSS	SPOP	0.9912	More...
Q99598	Translin-associated protein X	DEG_SPOP_SBC_1	29:33	VNSSS	SPOP	0.9939	More...
A6NGB9	WAS/WASL-interacting protein family member 3	DEG_SPOP_SBC_1	316:320	VNSSS	SPOP	0.946	More...
P51522	Zinc finger protein 83	DEG_SPOP_SBC_1	47:51	VNSSS	SPOP	0.6424	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1624:1628	VNSSS	SPOP	0.9986	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	123:127	VNSSS	SPOP	0.7274	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons