DegronMD - Q12889(OVGP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F395V	TCGA-A4-A5Y0	KIRP	TCGA	VNSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.1667
p.F395V	DO44463	KIRP	ICGC	VNSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.1667
p.G647E	TCGA-A5-A0G2	UCEC	TCGA	VTPQTS	DEG_SCF_FBW7_1	655:660	Mutation rewiring degron network	0.1111
p.G647E	DO41235	UCEC	ICGC	VTPQTS	DEG_SCF_FBW7_1	655:660	Mutation rewiring degron network	0.1111
p.E440A	TCGA-AG-A002	READ	TCGA	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.2778
p.L397M	TCGA-B5-A1MR	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.2222
p.L397M	DO41758	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.2222
p.S459F	TCGA-CV-A468	HNSC	TCGA	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.S459F	TCGA-CV-A468	HNSC	TCGA	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.25
p.S459F	TCGA-D3-A3ML	SKCM	TCGA	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.S459F	TCGA-D3-A3ML	SKCM	TCGA	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.25
p.S459F	TCGA-FW-A3R5	SKCM	TCGA	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.S459F	TCGA-FW-A3R5	SKCM	TCGA	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.25
p.S459F	DO52070	HNSC	ICGC	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.S459F	DO52070	HNSC	ICGC	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.25
p.S459F	DO37406	SKCM	ICGC	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.S459F	DO37406	SKCM	ICGC	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.25
p.S459F	DO47413	SKCM	ICGC	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.S459F	DO47413	SKCM	ICGC	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.25
p.S459F	ACH-001567	Skin Cancer	CCLE	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.S459F	ACH-001567	Skin Cancer	CCLE	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.25
p.T659A	TCGA-DU-6392	LGG	TCGA	VTPQTS	DEG_SCF_FBW7_1	655:660	Mutation altering degron motif	0.6028
p.T659A	DO22237	LGG	ICGC	VTPQTS	DEG_SCF_FBW7_1	655:660	Mutation altering degron motif	0.6028
p.G448D	TCGA-ER-A19H	SKCM	TCGA	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6087
p.G448D	DO47299	SKCM	ICGC	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6087
p.T454A	TCGA-O2-A52W	LUSC	TCGA	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation altering degron motif	0.6028
p.T454A	DO219225	LUSC	ICGC	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation altering degron motif	0.6028
p.A466D	DO229031	LICA	ICGC	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.0556
p.I645V	DO50950	LICA	ICGC	VTPQTS	DEG_SCF_FBW7_1	655:660	Mutation rewiring degron network	0.0556
p.T457I	DO23548	LIRI	ICGC	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.1111
p.T457I	DO23548	LIRI	ICGC	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.3056
p.M442R	DO220877	MELA	ICGC	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.8632
p.T415M	DO34136	PACA	ICGC	VNSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.0556
p.T415M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VNSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.0556
p.T415M	SIDM01664	Prostate Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.0556
p.S654P	DO33552	PACA	ICGC	VTPQTS	DEG_SCF_FBW7_1	655:660	Mutation rewiring degron network	0.3056
p.E667K	SIDM00491	Thyroid Gland Carcinoma	GDSC	VTPQTS	DEG_SCF_FBW7_1	655:660	Mutation rewiring degron network	0.1389
p.E667K	ACH-001443	Thyroid Cancer	CCLE	VTPQTS	DEG_SCF_FBW7_1	655:660	Mutation rewiring degron network	0.1389
p.E667K	ASH-3	thyroid	COSMIC	VTPQTS	DEG_SCF_FBW7_1	655:660	Mutation rewiring degron network	0.1389
p.S399F	SIDM00190	Melanoma	GDSC	VNSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.2778
p.S399F	ACH-002097	Skin Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.2778
p.S399F	CP66-MEL	skin	COSMIC	VNSSS	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.2778
p.N441K	SIDM01191	Osteosarcoma	GDSC	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.3056
p.N441K	SIDM01191	Osteosarcoma	GDSC	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.0556
p.N441K	ACH-000364	Primary	CCLE	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.3056
p.N441K	ACH-000364	Primary	CCLE	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.0556
p.N441K	U-2-OS	bone	COSMIC	MTITPRGT	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.3056
p.N441K	U-2-OS	bone	COSMIC	VTPTKE	DEG_SCF_FBW7_2	451:456	Mutation rewiring degron network	0.0556
p.P657T	SIDM01753	Gastric Carcinoma	GDSC	VTPQTS	DEG_SCF_FBW7_1	655:660	Mutation altering degron motif	0.7031
p.P657T	ACH-000239	Gastric Cancer	CCLE	VTPQTS	DEG_SCF_FBW7_1	655:660	Mutation altering degron motif	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OVGP1

UniProt ID: Q12889

Entrez ID: 5016

Protein name: Oviduct-specific glycoprotein (Estrogen-dependent oviduct protein) (Mucin-9) (Oviductal glycoprotein) (Oviductin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OVGP1 in