DegronMD

Uniprot ID: Q12889

Source protein: Oviduct-specific glycoprotein

Source gene: OVGP1

Class: DEG_SCF_FBW7_1

Location: 655:660

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 77.2833

COIL: 0.8377

CONS_SCORE: 0.5253

DSS_SCORE: 0.513

HELIX: 0.023

FCONS_SCORE: 1.3681

RIG_SCORE: 0.684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G647E	TCGA-A5-A0G2	UCEC	TCGA	VTPQTS	DEG_SCF_FBW7_1	0.1111
p.G647E	DO41235	UCEC	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.1111
p.T659A	TCGA-DU-6392	LGG	TCGA	VTPQTS	DEG_SCF_FBW7_1	0.6028
p.T659A	DO22237	LGG	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.6028
p.I645V	DO50950	LICA	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.0556
p.S654P	DO33552	PACA	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.3056
p.E667K	SIDM00491	Thyroid Gland Carcinoma	GDSC	VTPQTS	DEG_SCF_FBW7_1	0.1389
p.E667K	ACH-001443	Thyroid Cancer	CCLE	VTPQTS	DEG_SCF_FBW7_1	0.1389
p.E667K	ASH-3	thyroid	COSMIC	VTPQTS	DEG_SCF_FBW7_1	0.1389
p.P657T	SIDM01753	Gastric Carcinoma	GDSC	VTPQTS	DEG_SCF_FBW7_1	0.7031
p.P657T	ACH-000239	Gastric Cancer	CCLE	VTPQTS	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	DEG_SCF_FBW7_1	675:680	VTPQTS	FBXW7	0.7388	More...
Q12889	Oviduct-specific glycoprotein	DEG_SCF_FBW7_1	655:660	VTPQTS	FBXW7	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons