DegronMD

Uniprot ID: O15111

Source protein: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Source gene: CHUK

Class: DEG_SCF_FBW7_1

Location: 675:680

E3 ligase: FBXW7

DEGRON score: 0.7388

ASA_SCORE: 84.65

COIL: 0.8462

CONS_SCORE: 0.2706

DSS_SCORE: 0.477

HELIX: 0.121

FCONS_SCORE: 0.8904

RIG_SCORE: 0.7073

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L683M	TCGA-B5-A3FC	UCEC	TCGA	VTPQTS	DEG_SCF_FBW7_1	0.25
p.L683M	DO41871	UCEC	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.25
p.P685T	TCGA-CK-5916	COAD	TCGA	VTPQTS	DEG_SCF_FBW7_1	0.1944
p.P685T	DO8786	COAD	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.1944
p.P685L	TCGA-CM-6677	COAD	TCGA	VTPQTS	DEG_SCF_FBW7_1	0.1944
p.P685L	DO8570	COAD	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.1944
p.E672Q	TCGA-EA-A3HU	CESC	TCGA	VTPQTS	DEG_SCF_FBW7_1	0.25
p.E672Q	DO6320	CESC	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.25
p.E689K	TCGA-FV-A4ZP	LIHC	TCGA	VTPQTS	DEG_SCF_FBW7_1	0.0833
p.E689K	DO44911	LIHC	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.0833
p.T679K	DO228952	LICA	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.6195
p.A681E	DO228985	LICA	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.3056
p.W682R	DO229259	THCA	ICGC	VTPQTS	DEG_SCF_FBW7_1	0.2778

Drug responses associated with CHUK mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00533	PAAD\|pancreas	p.P239L (No)	GDSC	BMS-345541	17.8822
SIDM00841	COREAD\|large_intestine	p.W742* (No)	GDSC	BMS-345541	8.5828
SIDM01029	ESCA\|oesophagus	p.Q174H (No)	GDSC	BMS-345541	11.2159
SIDM01135	PAAD\|pancreas	p.M65L (No)	GDSC	BMS-345541	23.7404
SIDM00463	ALL\|lymphoblastic_T_cell_leukaemia	p.V155A (No)	GDSC	BMS-345541	3.6105
SIDM00355	LUAD\|lung_NSCLC_adenocarcinoma	p.L7fs*32 (No)	GDSC	BMS-345541	206.2075
SIDM00683	PRAD\|prostate	p.I590T (No)	GDSC	BMS-345541	17.3084
SIDM00683	PRAD\|prostate	p.M318T (No)	GDSC	BMS-345541	17.3084
SIDM00937	HNSC\|head_and_neck	p.K296E (No)	GDSC	BMS-345541	10.6674
SIDM00896	DLBC\|B_cell_lymphoma	p.E496D (No)	GDSC	BMS-345541	6.7826
SIDM00797	SKCM\|melanoma	p.S320F (No)	GDSC	BMS-345541	14.3175
SIDM00781	COREAD\|large_intestine	p.A451V (No)	GDSC	BMS-345541	13.9312
SIDM00893	BRCA\|breast	p.D102fs*20 (No)	GDSC	BMS-345541	23.0947
SIDM00214	COREAD\|large_intestine	p.V155A (No)	GDSC	BMS-345541	19.0299
SIDM00377	UNCLASSIFIED\|uterus	p.V155A (No)	GDSC	BMS-345541	14.6187
SIDM00516	SKCM\|melanoma	p.E585A (No)	GDSC	BMS-345541	5.2802
SIDM00498	COREAD\|large_intestine	p.P298A (No)	GDSC	BMS-345541	43.4049
SIDM00619	THCA\|thyroid	p.K109N (No)	GDSC	BMS-345541	5.7765
SIDM00079	OV\|ovary	p.I150fs*12 (No)	GDSC	BMS-345541	10.6168
SIDM00217	COREAD\|large_intestine	p.V211A (No)	GDSC	BMS-345541	12.3874
SIDM00217	COREAD\|large_intestine	p.V155A (No)	GDSC	BMS-345541	12.3874
SIDM00740	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.S263C (No)	GDSC	BMS-345541	17.8406
SIDM00359	COREAD\|large_intestine	p.A244V (No)	GDSC	BMS-345541	27.0417
SIDM00737	UNCLASSIFIED\|lung_NSCLC_not_specified	p.R143* (No)	GDSC	BMS-345541	34.528
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R646fs*22 (No)	GDSC	BMS-345541	15.1746
SIDM00375	HNSC\|head_and_neck	p.V155A (No)	GDSC	BMS-345541	36.1435
SIDM00589	HNSC\|head_and_neck	p.M507V (No)	GDSC	BMS-345541	20.2693
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.E704K (No)	GDSC	BMS-345541	13.3385
SIDM00487	COREAD\|large_intestine	p.M507fs*17 (No)	GDSC	BMS-345541	11.0835
SIDM00487	COREAD\|large_intestine	p.E712G (No)	GDSC	BMS-345541	11.0835
SIDM00136	COREAD\|large_intestine	p.I619T (No)	GDSC	BMS-345541	19.0426
SIDM00582	PAAD\|pancreas	p.K389* (No)	GDSC	BMS-345541	14.9265
SIDM00217	COREAD\|large_intestine	p.R646fs*22 (No)	GDSC	BMS-345541	12.3874
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A628V (No)	GDSC	BMS-345541	1.592
SIDM00360	UNCLASSIFIED\|pancreas	p.P548S (No)	GDSC	BMS-345541	68.6692
SIDM00444	ESCA\|oesophagus	p.R664W (Yes)	GDSC	BMS-345541	5.2375
SIDM00193	COREAD\|large_intestine	p.R104* (No)	GDSC	BMS-345541	26.5606
SIDM00193	COREAD\|large_intestine	p.E82* (No)	GDSC	BMS-345541	26.5606

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	DEG_SCF_FBW7_1	675:680	VTPQTS	FBXW7	0.7388	More...
Q12889	Oviduct-specific glycoprotein	DEG_SCF_FBW7_1	655:660	VTPQTS	FBXW7	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPQTS

Degron related mutations and impact score

Drug responses associated with CHUK mutations

All proteins holding degron of VTPQTS