DegronMD

Uniprot ID: Q12889

Source protein: Oviduct-specific glycoprotein

Source gene: OVGP1

Class: DEG_SCF_FBW7_2

Location: 451:456

E3 ligase: FBXW7

DEGRON score: 0.8993

ASA_SCORE: 95.2

COIL: 0.805

CONS_SCORE: 0.6331

DSS_SCORE: 0.5709

HELIX: 0.0137

FCONS_SCORE: 1.0494

RIG_SCORE: 0.7762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S459F	TCGA-CV-A468	HNSC	TCGA	VTPTKE	DEG_SCF_FBW7_2	0.25
p.S459F	TCGA-D3-A3ML	SKCM	TCGA	VTPTKE	DEG_SCF_FBW7_2	0.25
p.S459F	TCGA-FW-A3R5	SKCM	TCGA	VTPTKE	DEG_SCF_FBW7_2	0.25
p.S459F	DO52070	HNSC	ICGC	VTPTKE	DEG_SCF_FBW7_2	0.25
p.S459F	DO37406	SKCM	ICGC	VTPTKE	DEG_SCF_FBW7_2	0.25
p.S459F	DO47413	SKCM	ICGC	VTPTKE	DEG_SCF_FBW7_2	0.25
p.S459F	ACH-001567	Skin Cancer	CCLE	VTPTKE	DEG_SCF_FBW7_2	0.25
p.T454A	TCGA-O2-A52W	LUSC	TCGA	VTPTKE	DEG_SCF_FBW7_2	0.6028
p.T454A	DO219225	LUSC	ICGC	VTPTKE	DEG_SCF_FBW7_2	0.6028
p.A466D	DO229031	LICA	ICGC	VTPTKE	DEG_SCF_FBW7_2	0.0556
p.T457I	DO23548	LIRI	ICGC	VTPTKE	DEG_SCF_FBW7_2	0.3056
p.N441K	SIDM01191	Osteosarcoma	GDSC	VTPTKE	DEG_SCF_FBW7_2	0.0556
p.N441K	ACH-000364	Primary	CCLE	VTPTKE	DEG_SCF_FBW7_2	0.0556
p.N441K	U-2-OS	bone	COSMIC	VTPTKE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12889	Oviduct-specific glycoprotein	DEG_SCF_FBW7_2	451:456	VTPTKE	FBXW7	0.8993	More...
Q96T23	Remodeling and spacing factor 1	DEG_SCF_FBW7_2	407:412	VTPTKE	FBXW7	0.9704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons