DegronMD

Uniprot ID: Q96T23

Source protein: Remodeling and spacing factor 1

Source gene: RSF1

Class: DEG_SCF_FBW7_2

Location: 407:412

E3 ligase: FBXW7

DEGRON score: 0.9704

ASA_SCORE: 100.9667

COIL: 0.7492

CONS_SCORE: 0.3505

DSS_SCORE: 0.393

HELIX: 0.1722

FCONS_SCORE: 0.9314

RIG_SCORE: 0.7792

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E417K	TCGA-EE-A29D	SKCM	TCGA	VTPTKE	DEG_SCF_FBW7_2	0.1944
p.D413H	DO228471	BRCA	ICGC	VTPTKE	DEG_SCF_FBW7_2	0.3056
p.K411N	DO4942	BRCA	ICGC	VTPTKE	DEG_SCF_FBW7_2	0.5806
p.T416I	DO38153	SKCM	ICGC	VTPTKE	DEG_SCF_FBW7_2	0.2222
p.S400N	DO38183	STAD	ICGC	VTPTKE	DEG_SCF_FBW7_2	0.25
p.D420E	DO41331	UCEC	ICGC	VTPTKE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12889	Oviduct-specific glycoprotein	DEG_SCF_FBW7_2	451:456	VTPTKE	FBXW7	0.8993	More...
Q96T23	Remodeling and spacing factor 1	DEG_SCF_FBW7_2	407:412	VTPTKE	FBXW7	0.9704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons