DegronMD - Q96T23(RSF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1288D	TCGA-18-3411	LUSC	TCGA	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1111
p.W188C	TCGA-19-5956	GBM	TCGA	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.0556
p.W188C	DO13863	GBM	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.0556
p.D184Y	TCGA-19-5956	GBM	TCGA	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.1667
p.D184Y	TCGA-D1-A16Y	UCEC	TCGA	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.1667
p.D184Y	DO13863	GBM	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.1667
p.D184Y	DO41524	UCEC	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.1667
p.K565I	TCGA-33-AASI	LUSC	TCGA	ALSST	DEG_SPOP_SBC_1	555:559	Mutation substituting flanking lysine	0.2778
p.R1089Q	TCGA-42-2593	OV	TCGA	KRRRLNDLD	DEG_APCC_DBOX_1	1087:1095	Mutation altering degron motif	0.6218
p.I307S	TCGA-AP-A1DV	UCEC	TCGA	FKENV	DEG_APCC_KENBOX_2	315:319	Mutation rewiring degron network	0.1111
p.R1084Q	TCGA-AX-A2HA	UCEC	TCGA	KRRRLNDLD	DEG_APCC_DBOX_1	1087:1095	Mutation rewiring degron network	0.25
p.D549Y	TCGA-BH-A0DG	BRCA	TCGA	ALSST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1667
p.D549Y	TCGA-BS-A0UV	UCEC	TCGA	ALSST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1667
p.A1314T	TCGA-BR-4362	STAD	TCGA	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.0556
p.R1088H	TCGA-BS-A0TJ	UCEC	TCGA	KRRRLNDLD	DEG_APCC_DBOX_1	1087:1095	Mutation altering degron motif	0.8244
p.E417K	TCGA-EE-A29D	SKCM	TCGA	VTPTKE	DEG_SCF_FBW7_2	407:412	Mutation rewiring degron network	0.1944
p.R1297C	TCGA-EE-A2M5	SKCM	TCGA	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.8301
p.L550I	TCGA-F5-6814	READ	TCGA	ALSST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1944
p.S1296F	TCGA-GN-A8LK	SKCM	TCGA	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.6871
p.T559A	TCGA-OR-A5L5	ACC	TCGA	ALSST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.7139
p.E1092Q	DO534	BLCA	ICGC	KRRRLNDLD	DEG_APCC_DBOX_1	1087:1095	Mutation altering degron motif	0.6744
p.D413H	DO228471	BRCA	ICGC	VTPTKE	DEG_SCF_FBW7_2	407:412	Mutation rewiring degron network	0.3056
p.K411N	DO4942	BRCA	ICGC	VTPTKE	DEG_SCF_FBW7_2	407:412	Mutation altering degron motif	0.5806
p.E556D	DO8184	COAD	ICGC	ALSST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.6758
p.R326H	DO10020	COAD	ICGC	FKENV	DEG_APCC_KENBOX_2	315:319	Mutation rewiring degron network	0.1389
p.R326C	DO233156	GACA	ICGC	FKENV	DEG_APCC_KENBOX_2	315:319	Mutation rewiring degron network	0.1389
p.E1100Q	DO233672	GACA	ICGC	KRRRLNDLD	DEG_APCC_DBOX_1	1087:1095	Mutation rewiring degron network	0.1944
p.Q1082K	DO228978	LICA	ICGC	KRRRLNDLD	DEG_APCC_DBOX_1	1087:1095	Mutation rewiring degron network	0.1944
p.Q168K	DO229045	LICA	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.1944
p.I179V	DO231762	LINC	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.3056
p.P180L	DO231204	LUSC	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.2778
p.K313I	DO219129	LUSC	ICGC	FKENV	DEG_APCC_KENBOX_2	315:319	Mutation rewiring degron network	0.2778
p.G549R	DO220851	MELA	ICGC	ALSST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.1667
p.S186F	DO220877	MELA	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation blocking phosphorylation signal	0.5556
p.T178A	DO220906	MELA	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation altering degron motif	0.7139
p.D182G	DO228138	PBCA	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.2222
p.P1088S	DO219878	SKCA	ICGC	KRRRLNDLD	DEG_APCC_DBOX_1	1087:1095	Mutation altering degron motif	0.6752
p.G186W	DO37445	SKCM	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation blocking phosphorylation signal	0.5556
p.T416I	DO38153	SKCM	ICGC	VTPTKE	DEG_SCF_FBW7_2	407:412	Mutation rewiring degron network	0.2222
p.E165K	DO38123	SKCM	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.1111
p.E552K	DO47807	STAD	ICGC	ALSST	DEG_SPOP_SBC_1	555:559	Mutation rewiring degron network	0.25
p.S400N	DO38183	STAD	ICGC	VTPTKE	DEG_SCF_FBW7_2	407:412	Mutation substituting flanking lysine	0.25
p.R164Q	DO52412	UCEC	ICGC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.0833
p.A561S	DO41572	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	555:559	Mutation blocking phosphorylation signal	0.7222
p.D420E	DO41331	UCEC	ICGC	VTPTKE	DEG_SCF_FBW7_2	407:412	Mutation rewiring degron network	0.1111
p.K320N	DO43971	UCEC	ICGC	FKENV	DEG_APCC_KENBOX_2	315:319	Mutation blocking ubiquitination signal	0.75
p.R1299W	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.7523
p.R1299W	ACH-000697	Lymphoma	CCLE	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.7523
p.R1299W	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.7523
p.K548E	SIDM00600	Thyroid Gland Carcinoma	GDSC	ALSST	DEG_SPOP_SBC_1	555:559	Mutation substituting flanking lysine	0.25
p.K548E	ACH-001528	Thyroid Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	555:559	Mutation substituting flanking lysine	0.25
p.K548E	IHH-4	thyroid	COSMIC	ALSST	DEG_SPOP_SBC_1	555:559	Mutation substituting flanking lysine	0.25
p.R1299Q	SIDM00238	Ovarian Carcinoma	GDSC	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.6218
p.R1299Q	ACH-000947	Ovarian Cancer	CCLE	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.6218
p.R1299Q	OVK-18	ovary	COSMIC	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation altering degron motif	0.6218
p.S558F	SIDM00518	Mesothelioma	GDSC	ALSST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.7982
p.S558F	ACH-002136	Lung Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.7982
p.S558F	H290	pleura	COSMIC	ALSST	DEG_SPOP_SBC_1	555:559	Mutation altering degron motif	0.7982
p.R174K	SIDM00272	Breast Carcinoma	GDSC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation altering degron motif	0.6126
p.R174K	ACH-000910	Breast Cancer	CCLE	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation altering degron motif	0.6126
p.R174K	MDA-MB-453	breast	COSMIC	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation altering degron motif	0.6126
p.D1312G	SIDM00217	Colorectal Carcinoma	GDSC	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1111
p.D1312G	ACH-000999	Colon/Colorectal Cancer	CCLE	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1111
p.D1312G	SNU-1040	large intestine	COSMIC	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1111
p.E1288K	SIDM00937	Oral Cavity Carcinoma	GDSC	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1111
p.E1288K	ACH-000832	Head and Neck Cancer	CCLE	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1111
p.E1288K	CAL-27	upper aerodigestive tract	COSMIC	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.1111
p.V324A	SIDM01138	Pancreatic Carcinoma	GDSC	FKENV	DEG_APCC_KENBOX_2	315:319	Mutation rewiring degron network	0.1944
p.V324A	ACH-000139	Pancreatic Cancer	CCLE	FKENV	DEG_APCC_KENBOX_2	315:319	Mutation rewiring degron network	0.1944
p.V324A	PANC-03-27	pancreas	COSMIC	FKENV	DEG_APCC_KENBOX_2	315:319	Mutation rewiring degron network	0.1944
p.R1079G	ACH-000390	Lung Cancer	CCLE	KRRRLNDLD	DEG_APCC_DBOX_1	1087:1095	Mutation rewiring degron network	0.1111
p.D1306H	ACH-001412	Bladder Cancer	CCLE	SRKRLHRIE	DEG_APCC_DBOX_1	1296:1304	Mutation rewiring degron network	0.2778
p.K569Q	ACH-001460	Colon/Colorectal Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	555:559	Mutation substituting flanking lysine	0.1667
p.D182N	ACH-001607	Gallbladder Cancer	CCLE	VRMYIE	LIG_APCC_ABBA_1	173:178	Mutation rewiring degron network	0.2222
p.A561P	KP-4	pancreas	COSMIC	ALSST	DEG_SPOP_SBC_1	555:559	Mutation blocking phosphorylation signal	0.7222
p.S318F	SNU-81	large intestine	COSMIC	FKENV	DEG_APCC_KENBOX_2	315:319	Mutation altering degron motif	0.7982
p.S306F	H290	pleura	COSMIC	FKENV	DEG_APCC_KENBOX_2	315:319	Mutation substituting flanking lysine	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RSF1

UniProt ID: Q96T23

Entrez ID: 51773

Protein name: Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RSF1 in