DegronMD

Uniprot ID: Q96T23

Source protein: Remodeling and spacing factor 1

Source gene: RSF1

Class: LIG_APCC_ABBA_1

Location: 173:178

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7568

ASA_SCORE: 54.5667

COIL: 0.1483

CONS_SCORE: 0.4417

DSS_SCORE: 0.4101

HELIX: 0.0035

FCONS_SCORE: 0.9973

RIG_SCORE: 0.8373

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W188C	TCGA-19-5956	GBM	TCGA	VRMYIE	LIG_APCC_ABBA_1	0.0556
p.W188C	DO13863	GBM	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.0556
p.D184Y	TCGA-19-5956	GBM	TCGA	VRMYIE	LIG_APCC_ABBA_1	0.1667
p.D184Y	TCGA-D1-A16Y	UCEC	TCGA	VRMYIE	LIG_APCC_ABBA_1	0.1667
p.D184Y	DO13863	GBM	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.1667
p.D184Y	DO41524	UCEC	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.1667
p.Q168K	DO229045	LICA	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.1944
p.I179V	DO231762	LINC	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.3056
p.P180L	DO231204	LUSC	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.2778
p.S186F	DO220877	MELA	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.5556
p.T178A	DO220906	MELA	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.7139
p.D182G	DO228138	PBCA	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.2222
p.G186W	DO37445	SKCM	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.5556
p.E165K	DO38123	SKCM	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.1111
p.R164Q	DO52412	UCEC	ICGC	VRMYIE	LIG_APCC_ABBA_1	0.0833
p.R174K	SIDM00272	Breast Carcinoma	GDSC	VRMYIE	LIG_APCC_ABBA_1	0.6126
p.R174K	ACH-000910	Breast Cancer	CCLE	VRMYIE	LIG_APCC_ABBA_1	0.6126
p.R174K	MDA-MB-453	breast	COSMIC	VRMYIE	LIG_APCC_ABBA_1	0.6126
p.D182N	ACH-001607	Gallbladder Cancer	CCLE	VRMYIE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T23	Remodeling and spacing factor 1	LIG_APCC_ABBA_1	173:178	VRMYIE	APC,CDC20,FZR1	0.7568	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons