DegronMD

Uniprot ID: Q96T23

Source protein: Remodeling and spacing factor 1

Source gene: RSF1

Class: DEG_APCC_DBOX_1

Location: 1296:1304

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7257

ASA_SCORE: 123.6

COIL: 0.6841

CONS_SCORE: 0.3975

DSS_SCORE: 0.6712

HELIX: 0.2676

FCONS_SCORE: 0.9844

RIG_SCORE: 0.6381

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1288D	TCGA-18-3411	LUSC	TCGA	SRKRLHRIE	DEG_APCC_DBOX_1	0.1111
p.A1314T	TCGA-BR-4362	STAD	TCGA	SRKRLHRIE	DEG_APCC_DBOX_1	0.0556
p.R1297C	TCGA-EE-A2M5	SKCM	TCGA	SRKRLHRIE	DEG_APCC_DBOX_1	0.8301
p.S1296F	TCGA-GN-A8LK	SKCM	TCGA	SRKRLHRIE	DEG_APCC_DBOX_1	0.6871
p.R1299W	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRKRLHRIE	DEG_APCC_DBOX_1	0.7523
p.R1299W	ACH-000697	Lymphoma	CCLE	SRKRLHRIE	DEG_APCC_DBOX_1	0.7523
p.R1299W	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	SRKRLHRIE	DEG_APCC_DBOX_1	0.7523
p.R1299Q	SIDM00238	Ovarian Carcinoma	GDSC	SRKRLHRIE	DEG_APCC_DBOX_1	0.6218
p.R1299Q	ACH-000947	Ovarian Cancer	CCLE	SRKRLHRIE	DEG_APCC_DBOX_1	0.6218
p.R1299Q	OVK-18	ovary	COSMIC	SRKRLHRIE	DEG_APCC_DBOX_1	0.6218
p.D1312G	SIDM00217	Colorectal Carcinoma	GDSC	SRKRLHRIE	DEG_APCC_DBOX_1	0.1111
p.D1312G	ACH-000999	Colon/Colorectal Cancer	CCLE	SRKRLHRIE	DEG_APCC_DBOX_1	0.1111
p.D1312G	SNU-1040	large_intestine	COSMIC	SRKRLHRIE	DEG_APCC_DBOX_1	0.1111
p.E1288K	SIDM00937	Oral Cavity Carcinoma	GDSC	SRKRLHRIE	DEG_APCC_DBOX_1	0.1111
p.E1288K	ACH-000832	Head and Neck Cancer	CCLE	SRKRLHRIE	DEG_APCC_DBOX_1	0.1111
p.E1288K	CAL-27	upper_aerodigestive_tract	COSMIC	SRKRLHRIE	DEG_APCC_DBOX_1	0.1111
p.D1306H	ACH-001412	Bladder Cancer	CCLE	SRKRLHRIE	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T23	Remodeling and spacing factor 1	DEG_APCC_DBOX_1	1296:1304	SRKRLHRIE	APC,CDC20,FZR1	0.7257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons