DegronMD

Uniprot ID: Q96T23

Source protein: Remodeling and spacing factor 1

Source gene: RSF1

Class: DEG_SPOP_SBC_1

Location: 555:559

E3 ligase: SPOP

DEGRON score: 0.6085

ASA_SCORE: 84.36

COIL: 0.7648

CONS_SCORE: 0.3691

DSS_SCORE: 0.5943

HELIX: 0.1724

FCONS_SCORE: 0.8902

RIG_SCORE: 0.6269

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K565I	TCGA-33-AASI	LUSC	TCGA	ALSST	DEG_SPOP_SBC_1	0.2778
p.D549Y	TCGA-BH-A0DG	BRCA	TCGA	ALSST	DEG_SPOP_SBC_1	0.1667
p.D549Y	TCGA-BS-A0UV	UCEC	TCGA	ALSST	DEG_SPOP_SBC_1	0.1667
p.L550I	TCGA-F5-6814	READ	TCGA	ALSST	DEG_SPOP_SBC_1	0.1944
p.T559A	TCGA-OR-A5L5	ACC	TCGA	ALSST	DEG_SPOP_SBC_1	0.7139
p.E556D	DO8184	COAD	ICGC	ALSST	DEG_SPOP_SBC_1	0.6758
p.G549R	DO220851	MELA	ICGC	ALSST	DEG_SPOP_SBC_1	0.1667
p.E552K	DO47807	STAD	ICGC	ALSST	DEG_SPOP_SBC_1	0.25
p.A561S	DO41572	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	0.7222
p.K548E	SIDM00600	Thyroid Gland Carcinoma	GDSC	ALSST	DEG_SPOP_SBC_1	0.25
p.K548E	ACH-001528	Thyroid Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	0.25
p.K548E	IHH-4	thyroid	COSMIC	ALSST	DEG_SPOP_SBC_1	0.25
p.S558F	SIDM00518	Mesothelioma	GDSC	ALSST	DEG_SPOP_SBC_1	0.7982
p.S558F	ACH-002136	Lung Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	0.7982
p.S558F	H290	pleura	COSMIC	ALSST	DEG_SPOP_SBC_1	0.7982
p.K569Q	ACH-001460	Colon/Colorectal Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	0.1667
p.A561P	KP-4	pancreas	COSMIC	ALSST	DEG_SPOP_SBC_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	1048:1052	ALSST	SPOP	0.9809	More...
Q96GC6	Neurotrophin receptor-interacting factor homolog	DEG_SPOP_SBC_1	362:366	ALSST	SPOP	0.8364	More...
Q96T23	Remodeling and spacing factor 1	DEG_SPOP_SBC_1	555:559	ALSST	SPOP	0.6085	More...
Q9UBF2	Coatomer subunit gamma-2	DEG_SPOP_SBC_1	787:791	ALSST	SPOP	0.7115	More...
Q9Y5Y4	Prostaglandin D2 receptor 2	DEG_SPOP_SBC_1	389:393	ALSST	SPOP	0.9088	More...
Q7L1V2	Vacuolar fusion protein MON1 homolog B	DEG_SPOP_SBC_1	68:72	ALSST	SPOP	0.6448	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1158:1162	ALSST	SPOP	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons