ZNF274
UniProt ID: Q96GC6
Entrez ID: 10782
Protein name: Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) (Zinc finger protein HFB101) (Zinc finger protein with KRAB and SCAN domains 19) (Zinc finger protein zfp2) (Zf2)
External links: UniprotKB HGNC RefSeq COSMIC
Please click HERE
for better display.
FUNCTION: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exon...
FUNCTION: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). {ECO:0000269|PubMed:10777669, ECO:0000269|PubMed:27029610}.
View more >>
GO - Biological processes (BP):
negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of histone H3-K9 trimethylation [GO:1900112]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]...
negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of histone H3-K9 trimethylation [GO:1900112]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]
View more >>
GO - Molecular function (MF):
chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double...
chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]
View more >>
GO - Cellular component (CC):
cytoplasm [GO:0005737]; nucleolus [GO:0005730]...
cytoplasm [GO:0005737]; nucleolus [GO:0005730]
View more >>
ZNF274
Control panel
Show dataset:
Show Degron:
All sites
Degron
Degron
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for ZNF274 in
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc