DegronMD

Uniprot ID: Q96GC6

Source protein: Neurotrophin receptor-interacting factor homolog

Source gene: ZNF274

Class: DEG_SPOP_SBC_1

Location: 362:366

E3 ligase: SPOP

DEGRON score: 0.8364

ASA_SCORE: 81.14

COIL: 0.8178

CONS_SCORE: 0.5529

DSS_SCORE: 0.5582

HELIX: 0.159

FCONS_SCORE: 0.9822

RIG_SCORE: 0.7

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S363C	TCGA-33-AASL	LUSC	TCGA	ALSST	DEG_SPOP_SBC_1	0.7541
p.E367Q	TCGA-FR-A8YC	SKCM	TCGA	ALSST	DEG_SPOP_SBC_1	0.3056
p.R370P	DO234343	ESAD	ICGC	ALSST	DEG_SPOP_SBC_1	0.2222
p.L361I	DO46657	PAAD	ICGC	ALSST	DEG_SPOP_SBC_1	0.3056
p.E358K	DO218900	SKCA	ICGC	ALSST	DEG_SPOP_SBC_1	0.2222
p.L362V	NCI-H740	lung	COSMIC	ALSST	DEG_SPOP_SBC_1	0.6765
p.M355L	RERF-LC-Sq1	lung	COSMIC	ALSST	DEG_SPOP_SBC_1	0.1389
p.M355L	KYAE-1	oesophagus	COSMIC	ALSST	DEG_SPOP_SBC_1	0.1389
p.L352V	NCI-H740	lung	COSMIC	ALSST	DEG_SPOP_SBC_1	0.0556
p.M355I	KYAE-1	oesophagus	COSMIC	ALSST	DEG_SPOP_SBC_1	0.1389
p.M355I	RERF-LC-Sq1	lung	COSMIC	ALSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	1048:1052	ALSST	SPOP	0.9809	More...
Q96GC6	Neurotrophin receptor-interacting factor homolog	DEG_SPOP_SBC_1	362:366	ALSST	SPOP	0.8364	More...
Q96T23	Remodeling and spacing factor 1	DEG_SPOP_SBC_1	555:559	ALSST	SPOP	0.6085	More...
Q9UBF2	Coatomer subunit gamma-2	DEG_SPOP_SBC_1	787:791	ALSST	SPOP	0.7115	More...
Q9Y5Y4	Prostaglandin D2 receptor 2	DEG_SPOP_SBC_1	389:393	ALSST	SPOP	0.9088	More...
Q7L1V2	Vacuolar fusion protein MON1 homolog B	DEG_SPOP_SBC_1	68:72	ALSST	SPOP	0.6448	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1158:1162	ALSST	SPOP	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons