DegronMD

Uniprot ID: Q9Y5Y4

Source protein: Prostaglandin D2 receptor 2

Source gene: PTGDR2

Class: DEG_SPOP_SBC_1

Location: 389:393

E3 ligase: SPOP

DEGRON score: 0.9088

ASA_SCORE: 81.36

COIL: 0.8654

CONS_SCORE: 0.3026

DSS_SCORE: 0.8305

HELIX: 0.0938

FCONS_SCORE: 0.7594

RIG_SCORE: 0.6712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R388P	DO229363	BTCA	ICGC	ALSST	DEG_SPOP_SBC_1	0.3056
p.Q382H	DO229053	LICA	ICGC	ALSST	DEG_SPOP_SBC_1	0.1389
p.L386M	DO229227	THCA	ICGC	ALSST	DEG_SPOP_SBC_1	0.25
p.S395T	ACH-000910	Breast Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	1048:1052	ALSST	SPOP	0.9809	More...
Q96GC6	Neurotrophin receptor-interacting factor homolog	DEG_SPOP_SBC_1	362:366	ALSST	SPOP	0.8364	More...
Q96T23	Remodeling and spacing factor 1	DEG_SPOP_SBC_1	555:559	ALSST	SPOP	0.6085	More...
Q9UBF2	Coatomer subunit gamma-2	DEG_SPOP_SBC_1	787:791	ALSST	SPOP	0.7115	More...
Q9Y5Y4	Prostaglandin D2 receptor 2	DEG_SPOP_SBC_1	389:393	ALSST	SPOP	0.9088	More...
Q7L1V2	Vacuolar fusion protein MON1 homolog B	DEG_SPOP_SBC_1	68:72	ALSST	SPOP	0.6448	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1158:1162	ALSST	SPOP	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons