DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SPOP_SBC_1

Location: 1048:1052

E3 ligase: SPOP

DEGRON score: 0.9809

ASA_SCORE: 76.54

COIL: 0.7266

CONS_SCORE: 0.3647

DSS_SCORE: 0.6137

HELIX: 0.0272

FCONS_SCORE: 0.9133

RIG_SCORE: 0.6996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1050I	TCGA-17-Z045	LUAD	TCGA	ALSST	DEG_SPOP_SBC_1	0.7341
p.Q1040H	TCGA-AX-A2HC	UCEC	TCGA	ALSST	DEG_SPOP_SBC_1	0.1111
p.Q1040H	DO41572	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	0.1111
p.K1057N	TCGA-AX-A2HC	UCEC	TCGA	ALSST	DEG_SPOP_SBC_1	0.3056
p.K1057N	DO41572	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	0.3056
p.E1058K	TCGA-QB-A6FS	SKCM	TCGA	ALSST	DEG_SPOP_SBC_1	0.1667
p.E1058K	DO48654	SKCM	ICGC	ALSST	DEG_SPOP_SBC_1	0.1667
p.S1050G	DO233760	GACA	ICGC	ALSST	DEG_SPOP_SBC_1	0.6993
p.A1053S	DO233951	GACA	ICGC	ALSST	DEG_SPOP_SBC_1	0.3056
p.E1043D	SIDM01611	Endometrial Carcinoma	GDSC	ALSST	DEG_SPOP_SBC_1	0.1944
p.E1043D	ACH-000996	Endometrial/Uterine Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	0.1944
p.R1038M	LoVo	large_intestine	COSMIC	ALSST	DEG_SPOP_SBC_1	0.1667
p.G1048D	KM12	large_intestine	COSMIC	ALSST	DEG_SPOP_SBC_1	0.7198
p.K1045T	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	ALSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	1048:1052	ALSST	SPOP	0.9809	More...
Q96GC6	Neurotrophin receptor-interacting factor homolog	DEG_SPOP_SBC_1	362:366	ALSST	SPOP	0.8364	More...
Q96T23	Remodeling and spacing factor 1	DEG_SPOP_SBC_1	555:559	ALSST	SPOP	0.6085	More...
Q9UBF2	Coatomer subunit gamma-2	DEG_SPOP_SBC_1	787:791	ALSST	SPOP	0.7115	More...
Q9Y5Y4	Prostaglandin D2 receptor 2	DEG_SPOP_SBC_1	389:393	ALSST	SPOP	0.9088	More...
Q7L1V2	Vacuolar fusion protein MON1 homolog B	DEG_SPOP_SBC_1	68:72	ALSST	SPOP	0.6448	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1158:1162	ALSST	SPOP	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons