PTGDR2
UniProt ID: Q9Y5Y4
Entrez ID: 11251
Protein name: Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 inter...
FUNCTION: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
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GO - Biological processes (BP):
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; negative regulation of male germ cell proliferation [GO:2...
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; negative regulation of male germ cell proliferation [GO:2000255]; neuropeptide signaling pathway [GO:0007218]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]
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GO - Molecular function (MF):
G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; peptide binding [GO:0042277]; prostaglandin D receptor activity [GO:0004956]; prostaglandin F receptor activity [GO:0004958]; prostaglandin J receptor activity [GO:0001785]...
G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; peptide binding [GO:0042277]; prostaglandin D receptor activity [GO:0004956]; prostaglandin F receptor activity [GO:0004958]; prostaglandin J receptor activity [GO:0001785]
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GO - Cellular component (CC):
integral component of plasma membrane [GO:0005887]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]...
integral component of plasma membrane [GO:0005887]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]
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PTGDR2
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*NOTE: the Kaplan plots were collected from OncoLnc